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Prognostic value of lipid levels in short-term outcome after TAVI

机译：Tavi后短期结果的脂质水平的预后价值

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Background A satisfactory risk score specific to transaortic valve implantation (TAVI) procedure is strongly needed for accurate assessment of postprocedural mortality and outcome. The purpose of this study was to investigate the association between certain clinical and laboratory parameters, particularly serum cholesterol levels, and major adverse cardiac events in patients who underwent TAVI. Method We retrospectively analyzed 119 patients who underwent TAVI at our institution between 2008 and 2016. The independent relationship between clinical and laboratory parameters and major adverse cardiac and cerebrovascular events (MACCE) was analyzed by regression analysis. Results In all, 34 patients (28%) experienced MACCE during hospitalization and within 30 days of the procedure. Low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) levels were significantly lower in the MACCE(+) group compared with the MACCE(-) group (91.9 +/- 38 vs. 110.8 +/- 38.1 mg/dl,p = 0.01; 33.7 +/- 7.3 vs. 38.1 +/- 9.8 mg/dl,p = 0.02, respectively). In multivariate logistic regression analysis, age, white blood cell count (WBC), and lower levels of LDL-C and HDL-C were found to be independently correlated with MACCE in the study population. Receiver operating curve (ROC) analysis revealed that an LDL value higher than 71 mg/dl predicted MACCE with a sensitivity of 45.4% and a specificity of 91.8% (AUC: 0.814;p = 0.02). Conclusion This study suggests that lower serum LDL-C and HDL-C levels are independently associated with short-term MACCE in post-TAVI patients. Lower levels of LDL and HDL cholesterol may indicate a poor prognosis. Measurement of serum lipid levels might improve the preoperative risk assessment of potential TAVI candidates.
机译：背景技术强烈需要对经型阀门注入（TAVI）程序进行令人满意的风险评分，以便准确评估后期死亡率和结果。本研究的目的是研究某些临床和实验室参数，特别是血清胆固醇水平的关联，以及接受TAVI的患者的主要不良心脏事件。我们回顾性地分析了2008年至2016年在我们的机构接受了Tavi的119名患者。通过回归分析分析了临床和实验室参数和主要不良心和脑血管事件（MACCE）之间的独立关系。结果所有，34名患者（28％）在住院期间经历了宏观，在手术后30天内。与MACCE（+）组相比，低密度脂蛋白胆固醇（LDL-C）和高密度脂蛋白胆固醇（HDL-C）水平显着降低（91.9 +/- 38对110.8 + / - 38.1mg / dl，p = 0.01; 33.7 +/- 7.3与38.1 +/- 9.8 mg / dl，p = 0.02分别）。在多变量逻辑回归分析中，发现年龄，白细胞计数（WBC）和较低水平的LDL-C和HDL-C与研究人群中的MAC独立相关。接收器操作曲线（ROC）分析表明，高于71mg / dL的LDL值预测的宏观敏感性为45.4％，特异性为91.8％（AUC：0.814; P = 0.02）。结论本研究表明，下育龄术患者中，较低的血清LDL-C和HDL-C水平与短期MACCE独立相关。较低水平的LDL和HDL胆固醇可能表明预后差。测量血清脂质水平可能改善潜在的TAVI候选人的术前风险评估。

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