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首页> 外文期刊>HLA. >ABOABO blood group phenotype frequency estimation using molecular phenotyping in rhesus and cynomolgus macaques
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ABOABO blood group phenotype frequency estimation using molecular phenotyping in rhesus and cynomolgus macaques

机译： abo abo血液组表型使用岩石中的分子表型和cynomolgus macaques

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xml:id="tan13118-para-0001"> A much larger sample ( N = 2369) was used to evaluate a previously reported distribution of the A, AB and B blood group phenotypes in rhesus and cynomolgus macaques from six different regional populations. These samples, acquired from 15 different breeding and research facilities in the United States, were analyzed using a real‐time quantitative polymerase chain reaction ( qPCR ) assay that targets single nucleotide polymorphisms ( SNPs ) responsible for the macaque A, B and AB phenotypes. The frequency distributions of blood group phenotypes of the two species differ significantly from each other and significant regional differentiation within the geographic ranges of each species was also observed. The B blood group phenotype was prevalent in rhesus macaques, especially those from India, while the frequencies of the A, B and AB phenotypes varied significantly among cynomolgus macaques from different geographic regions. The Mauritian cynomolgus macaques, despite having originated in Indonesia, showed significant ( P ? .01) divergence from the Indonesian animals at the ABO blood group locus. Most Mauritian animals belonged to the B blood group while the Indonesian animals were mostly A. The close similarity in blood group frequency distributions between the Chinese rhesus and Indochinese cynomolgus macaques demonstrates that the introgression between these two species extends beyond the zone of intergradation in Indochina. This study underscores the importance of ABO blood group phenotyping of the domestic supply of macaques and their biospecimens.
机译： xml：id =“tan13118-para-0001”>使用更大的样品（ n = 2369）来评估先前报告的A， AB 和B血液组表型从六种不同区域的羊毛群中的分布人口。通过实时定量聚合酶链反应（ QPCR ）测定，分析来自美国15种不同育种和研究设施的样本，其靶向单核苷酸多态性（ SNPS ）负责猕猴A，B和 Ab 表型。两种物种的血型成像型的频率分布显着不同，并且还观察到每种物种的地理范围内的显着区域分化。 B血型表型在恒河猴中普遍存在，特别是来自印度的，而a，b和 ab 表型在来自不同地理区域的鱼糜猕猴中的频率显着变化。尽管起源于印度尼西亚，Mauritian Cynomolgus Macaques表现出了来自印度尼西亚动物在 ABO 血液组基因座中的重要（ p Δω01）。大多数毛里求斯动物属于B血集团，而印度尼西亚动物大多是A.中国恒河和吲哚莫马莫莫氏菌之间的血型频率分布的密切相似性表明这两个物种之间的速降延伸到印度吲哚靛蓝的互补区之外。本研究强调了 ABO 血型表型对猕猴及其生物学的血型表型表型的重要性。

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