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首页> 外文期刊>Trends in Ecology & Evolution >In vitro and in vivo evaluations of nano-hydroxyapatite/polyamide 66/yttria-stabilized zirconia as a novel bioactive material for bone screws: Biocompatibility and bioactivity
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In vitro and in vivo evaluations of nano-hydroxyapatite/polyamide 66/yttria-stabilized zirconia as a novel bioactive material for bone screws: Biocompatibility and bioactivity

机译：体外和体内评价纳米羟基磷灰石/聚酰胺66 / yttra稳定的氧化锆作为骨螺钉的新型生物活性材料：生物相容性和生物活性

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摘要

Zirconia and its derivatives have been receiving increased levels of attention with regard to their potential application in bone tissue engineering. These materials are of particular interest because of their excellent characteristics, such as superior biological and mechanical properties. In this study, yttria-stabilized tetragonal zirconia (YTZ)-reinforced nanohydroxyapatite/polyamide 66 (nHA/PA66) bone screws were prepared. The biocompatibility and bioactivity of nHA/PA66/YTZ were evaluated in vitro using MC3T3-E1 cells. Biocompatibility and bioactivity experiments (cell counting kit-8 tests, cell immunofluorescence analysis, and polymerase chain reaction) showed that nHA/PA66/YTZ could facilitate the biological functions of MC3T3-E1 cells. The attachment, proliferation, spreading, and expression of genes associated with osteogenesis (collagen 1, osteopontin, and osteocalcin) in cells cultured with the nHA/PA66/YTZ composite were all superior compared with the control groups (P < 0.05). In addition, nHA/PA66/YTZ bone screws were implanted into the femoral condyles of rabbits, and titanium screws were employed as a control group; postoperative histology and blood analysis revealed no obvious damage to the liver, kidneys, or any other major organs in either of the experimental groups. Moreover, nHA/PA66/YTZ screws resulted in significantly better bone-implant contact interfaces and enhanced formation of trabecular bone (P < 0.05); these characteristics were markedly better than those in the group that received titanium screws. These observations indicate that YTZ-reinforced nHA/PA66 composites have significant potential for applications in bone tissue engineering.
机译：氧化锆及其衍生物在骨组织工程中的潜在应用方面得到了更多的关注水平。由于其优异的特性，例如优异的生物和机械性能，这些材料特别感兴趣。在该研究中，制备了yTTRIA稳定的四方氧化锆（YTZ） - 重新裂解的纳米羟基磷灰石/聚酰胺66（NHA / PA66）骨螺钉。使用MC3T3-E1细胞在体外评估NHA / PA66 / YTZ的生物相容性和生物活性。生物相容性和生物活性实验（Cell计数试剂盒-8试验，细胞免疫荧光分析和聚合酶链反应）表明NHA / PA66 / YTZ可以促进MC3T3-E1细胞的生物学功能。与NHA / PA66 / YTZ复合材料培养的细胞中的骨质发生（胶原1，骨桥蛋白和骨液）相关的基因的附着，增殖，扩散和表达与对照组相比，均优越（P <0.05）。此外，NHA / PA66 / YTZ骨螺钉植入兔的股骨髁，用钛螺钉作为对照组;术后组织学和血液分析显示对肝脏，肾脏或任何实验组中的任何其他主要器官没有明显的损害。此外，NHA / PA66 / YTZ螺钉导致了更好的骨植入接触界面和细胞面向骨的形成增强（P <0.05）;这些特性显着优于接收钛螺钉的组中的特征。这些观察结果表明，YTZ加强的NHA / PA66复合材料具有骨组织工程中应用的显着潜力。

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  • 来源
    《Trends in Ecology & Evolution》 |2020年第1期|共15页
  • 作者

    Li Yu-Ling; Zhao Wei-Kang; Zhang Jing; Xiang Chao; Chen Qian; Yan Caiping; Jiang Ke;

  • 作者单位

    North Sichuan Med Coll Dept Orthopaed Affiliated Hosp 63 Wenhua Rd Nanchong City Sichuan Peoples R China;

    Chongqing Med Univ Dept Orthopaed Affiliated Hosp 1 Chongqing Peoples R China;

    North Sichuan Med Coll Dept Gastroenterol Affiliated Hosp Nanchong City Peoples R China;

    North Sichuan Med Coll Dept Orthopaed Affiliated Hosp 63 Wenhua Rd Nanchong City Sichuan Peoples R China;

    North Sichuan Med Coll Dept Orthopaed Affiliated Hosp 63 Wenhua Rd Nanchong City Sichuan Peoples R China;

    North Sichuan Med Coll Dept Orthopaed Affiliated Hosp 63 Wenhua Rd Nanchong City Sichuan Peoples R China;

    North Sichuan Med Coll Dept Orthopaed Affiliated Hosp 63 Wenhua Rd Nanchong City Sichuan Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 数学生态学与生物模型;
  • 关键词

    Zirconia; orthopedic biomaterials; bioactivity; biocompatibility; bone tissue engineering;

    机译：氧化锆;矫形生物材料;生物相活性;生物相容性;骨组织工程;

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