• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Trends in Ecology & Evolution >Eosinophilic pneumonia during treatment with clozapine: reports from a retrospective case series
【24h】

Eosinophilic pneumonia during treatment with clozapine: reports from a retrospective case series

机译：用氯氮平治疗期间嗜酸性肺炎：回顾性案例系列的报道

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Clozapine is an atypical antipsychotic known to cause multiple hematologic abnormalities, most seriously agranulocytosis, but also notably eosinophilia. It is considered as an allergic reaction with a spontaneous remission, however, sometimes, it may predict subsequent major inflammatory complications. The aim of this study was to investigate the relationship between clozapine usage and drug-induced pneumonia based on characteristic respiratory symptoms and radiological findings, retrospectively in 69 Japanese treatment-resistant schizophrenia patients. Comparisons of the 26 weeks consecutive levels: white blood cell count with neutrophil and eosinophil, relative to their baseline levels were performed within total subjects and two groups divided by the findings of pneumonia. The crude odds ratios with 95% confidence intervals for developing pneumonia and potential confounders were calculated. The levels of eosinophils significantly increased at 1 month in each group. The introduction season between October and January and higher eosinophil level at first month were correlated with the risk of pneumonia, which occurred independent of clozapine dosage and term and relapsed in subjects when developed within initial 1 month. Clozapine-induced eosinophilic pneumonia was considered transient and reversible, however, the risks and benefits must be considered and close monitoring should be done to avoid life-threatening conditions during clozapine treatment.
机译：氯氮平是一种熟悉血液学异常，最严重的血液细胞症，也是嗜酸性粒细胞增强的非典型抗精神病药。它被认为是具有自发缓解的过敏反应，但有时，它可能预测后续的主要炎症并发症。本研究的目的是研究基于特征呼吸系统症状和放射生理学发现的氯氮平使用和药物诱导的肺炎之间的关系，回顾69例日本治疗抗性精神分裂症患者。连续26周的比较：与中性粒细胞和嗜酸性粒细胞的白细胞计数相对于其基线水平在总受试者中进行，两组除以肺炎的研究结果。计算出患肺炎和潜在混血剂的95％置信区间的粗差异比率。每组1个月的嗜酸性粒细胞水平明显增加。第一月和1月份的引入季节和嗜酸氢粒细胞水平在第一个月与肺炎的风险有关，这些风险与氯氮平剂量和术语无关，并在最初的1个月内开发时在受试者中复发。氯氮平诱导的嗜酸性嗜酸性肺炎被认为是瞬态和可逆的，然而，必须考虑的风险和效益，并应对氯氮平治疗期间避免危及生命的病症。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号