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首页> 外文期刊>Trends in Ecology & Evolution >Rhombencephalitis in Children: Diffusion Magnetic Resonance Imaging (MRI) Correlation With Clinical Outcomes
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Rhombencephalitis in Children: Diffusion Magnetic Resonance Imaging (MRI) Correlation With Clinical Outcomes

机译：儿童脑膜炎：扩散磁共振成像（MRI）与临床结果的相关性

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摘要

In children with rhombencephalitis, neuroimaging abnormalities have been infrequently correlated with clinical outcome. We investigated whether magnetic resonance (MR) neuroimaging studies could predict clinical outcomes and disturbance of consciousness in patients with rhombencephalitis. We retrospectively analyzed the MR studies of 19 pediatric patients with rhombencephalitis (median age: 4.2 years, range 0.5-17; sex: 32% male). Fluid-attenuated inversion recovery imaging and diffusion-weighted imaging findings were graded to create imaging scores according to the extent of imaging abnormality. Clinical outcomes in the first week and 12th month were graded by using Glasgow Outcome Scale scores (1-5) and dichotomized to unfavorable or favorable outcome. Correlations of the imaging scores with the clinical outcomes and with disturbance of consciousness were assessed by using multivariate logistic regression analysis. No significant correlation was found between fluid-attenuated inversion recovery score or diffusion-weighted imaging score (P = .608, P = .132, respectively) and disturbance of consciousness. In the first week, the unfavorable outcome group (n = 11) had significantly higher diffusion-weighted imaging score than did the favorable outcome group (n = 8) (Mann-Whitney U test, P = .005). Multivariate logistic regression analysis showed that the diffusion-weighted imaging score (odds ratio, 18.182; 95% confidence interval: 1.36, 243.01; P = .028) was significantly associated with unfavorable outcome. In the 12th month, the fluid-attenuated inversion recovery score or diffusion-weighted imaging score (P = .994, P = .997, respectively) were not significantly associated with unfavorable outcome. Patients with rhombencephalitis who have a higher diffusion-weighted imaging score are more likely to have an unfavorable 1-week clinical outcome.
机译：在患有脑脑炎的儿童中，神经成像异常与临床结果不经常相关。我们调查了磁共振（MR）神经影像学研究是否可以预测患有菌脑炎患者的临床结果和意识的扰动。我们回顾性分析了19例菌脑炎的19例儿科患者的研究（中位数：4.2岁，范围为0.5-17;性别：32％男性）。分级流体减毒的反转恢复成像和扩散加权成像发现以根据成像异常的程度来产生成像分数。第一周和第12个月的临床结果是通过使用Glasgow结果规模分数（1-5）和二分作化为不利或有利的结果进行分级。通过使用多元逻辑回归分析评估了成像评分与临床结果和意识扰动的相关性。在流体衰减的反转恢复得分或扩散加权成像评分（P = .608，P = .132）之间没有发现显着的相关性和意识的扰动。在第一周，不利的结果组（n = 11）显着提高扩散加权成像分数，而不是有利的结果组（n = 8）（Mann-Whitney U测试，P = .005）。多变量逻辑回归分析表明，扩散加权成像评分（差距比，18.182; 95％置信区间：1.36,243.01; p = .028）与不利的结果显着相关。在第12个月，流体衰减的反转恢复得分或扩散加权成像评分（P = .994，P = .997）与不利的结果没有显着相关。患有较高的扩散加权成像评分的脑膜炎患者更可能具有不利的1周临床结果。

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