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首页> 外文期刊>AJOB Primary Research >Participants' Perceptions of Deep Brain Stimulation Research for Treatment-Resistant Depression:Risks, Benefits, and Therapeutic Misconception
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Participants' Perceptions of Deep Brain Stimulation Research for Treatment-Resistant Depression:Risks, Benefits, and Therapeutic Misconception

机译：参与者对抗治疗性抑郁症的深部脑刺激研究的看法：风险，益处和治疗误解

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Background:Deep brain stimulation (DBS) for treatment-resistant depression (TRD) is the focus of great interest and numerous studies. Given the state of this research, the risks of DBS, the uncertainty of direct benefits, and the potential for therapeutic misconception (TM), examination of research participants' perspectives is critical to addressing concerns about the adequacy of consent among people with TRD. Methods: Among 31 participants considering DBS studies at two sites, self-report questionnaires were used to examine three dimensions of TM (eight true/false items). Additional Likert-scale items assessed perceptions of risks, potential benefits, and altruistic motivations. Results: Participants correctly identified the surgery itself as the riskiest study procedure, although only four participants rated the surgery as "high risk." Most participants rated the entire DBS study as "moderate" or lower risk. Participants rated the likelihood of others benefiting in the future more strongly than they did the likelihood of personal benefit. Participants held positive attitudes toward research, and were moderately altruistic. Nearly two-thirds of the 31 participants (64.5%) answered at least one of the true/false TM items incorrectly. Conclusions: Individuals considering DBS studies for TRD demonstrated reasonable perceptions of risks and benefits, distinguished among procedural risks, and expressed hopes for personal benefit as well as altruism. Findings related to TM were mixed: Participants understood the experimental stage of DBS for depression and endorsed the possibility of no personal benefit, yet there was some evidence for TM. Although these findings are reassuring, investigators must nevertheless remain vigilant about identifying and addressing potential misconceptions.
机译：背景：针对难治性抑郁症（TRD）的深层脑刺激（DBS）是引起人们极大兴趣和众多研究的焦点。考虑到这项研究的现状，DBS的风险，直接收益的不确定性以及治疗性误解（TM）的可能性，研究参与者的观点的审查对于解决TRD患者对同意是否足够的担忧至关重要。方法：在考虑在两个地点进行DBS研究的31名参与者中，使用自我报告问卷调查了TM的三个维度（八个正确/错误项目）。额外的李克特量表项目评估了对风险，潜在利益和利他动机的看法。结果：尽管只有四名参与者将手术评定为“高风险”，但参与者正确地认为手术本身是最危险的研究程序。大多数参与者将整个DBS研究评为“中等”或较低风险。与他人个人受益的可能性相比，参与者对他人将来受益的可能性的评价更为强烈。参加者对研究持积极态度，并具有一定的利他态度。 31名参与者中有近三分之二（64.5％）错误地回答了真假TM项目中的至少一项。结论：考虑将DBS研究用于TRD的个人表现出对风险和收益的合理认识，区分了程序风险，并对个人收益和利他主义表示希望。与TM相关的发现参差不齐：参与者了解DBS抑郁症的实验阶段，并认可没有个人利益的可能性，但仍有一些TM证据。尽管这些发现令人放心，但调查人员仍必须保持警惕，以发现和解决潜在的误解。

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