• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Human Immunology: Official Journal of the American Society for Histocompatibility and Immunogenetics >Double positive CD4+CD8+T cells are part of the adaptive immune response against Candida albicans
【24h】

Double positive CD4+CD8+T cells are part of the adaptive immune response against Candida albicans

机译：双阳性CD4 + CD8 + T细胞是针对念珠菌阿巴文人的适应性免疫应答的一部分

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Although multiple immune cells participate in the innate and adaptive immune response against Candida albicans, the elucidation of cellular and inflammation kinetics may be a promising strategy to decipher events propitious to infection eradication. We used an in vitro Candida-human leucocyte coculture approach to study the dynamics of rare CD4 + CD8 + double positive T lymphocytes (DP T) produced in response to this fungus. Our results highlight the presence of two phenotypically distinct subsets of DP T cells: CD4hiCD8lo and CD4loCD8hi, and that the different ratio of these cells correlates with infection outcome. The ratio of CD4hiCD8lo over CD4loCD8hi by day 6 was significantly higher in controlled infections and decreased when infection persisted due to a significant increase in the proportion of CD4loCD8hi. When infection was controlled, CD4hiCD8lo T cells secreted IFN gamma, TNF alpha, IL-4 and IL-10 cytokines two days after challenge. By day 2, under conditions of persistent infection, CD4hiCD8lo and CD4loCD8hi T cells secreted significant levels of IL-4 and IL-10, respectively, compared to uninfected cultures. Frequency kinetics and original cytokine profiles detailed in this work indicate that DP T cells could participate in the adaptive immune response to C. albicans.
机译：虽然多种免疫细胞参与对念珠菌蛋白的先天和适应性免疫应答，但细胞和炎症动力学的阐明可能是解构缺乏感染事件的有希望的策略。我们使用了体外念珠菌 - 人类白细胞共培养方法来研究罕见的CD4 + CD8 +双阳性T淋巴细胞（DP T）的动力学，响应该真菌。我们的结果突出了两种表型不同的DP T细胞亚群：CD4HICD8LO和CD4LOCD8HI，并且这些细胞的不同比例与感染结果相关联。在第6天通过CD4LoCD8HI的CD4HICD8LO与受控感染的比例显着高，并且由于CD4LOCD8HI比例的显着增加，感染持续存在时的减少。当控制感染时，CD4HICD8LO T细胞在攻击后两天分泌IFNγ，TNFα，IL-4和IL-10细胞因子。在第2天，在持续感染的条件下，与未感染的培养物相比，CD4HICD8LO和CD4LOO和CD4LOCD8HI T细胞分别分别分别分别分别为IL-4和IL-10。本作作品中详述的频率动力学和原始细胞因子谱表明DP T细胞可以参与对白醛癌的适应性免疫应答。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号