• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Biotechnology Progress >On the Choice of the Optimal Periodic Operation for a Continuous Fermentation Process
【24h】

On the Choice of the Optimal Periodic Operation for a Continuous Fermentation Process

机译：连续发酵过程中最佳周期操作的选择

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In this contribution we investigate the impact of the forcing waveform on the productivity of a continuous bioreactor governed by an unstructured, nonlinear kinetic model. The (periodic) forcing is applied on the substrate concentration in the feed. To this end, some alternative waveforms commonly encountered in practice are evaluated and their performance is compared. An analyticalumerical approach is used. The preliminary analytical step is based on the π-crite-rion that gives useful information for small amplitudes. The extension to larger amplitudes, when significant improvements are expected, is then performed through a continuation-optimization procedure. It is found that the choice of the specific waveform has an impact on the performance of the process and there is no unique best forcing for any process condition, but its choice depends on the operating parameters and the forcing amplitude and frequency values. Further, the influence of the waveform functions on the wash-out conditions are extensively examined. The analysis shows that all the waveforms examined in this work may lead to significant enlargement of the nontrivial regime with respect to a steady state operation. In particular, square-wave forcing leads in practice to the extinction of the wash-out conditions for any feed substrate concentration and for a well defined choice of the forcing parameters.
机译：在这一贡献中，我们研究了强制波形对由非结构化非线性动力学模型控制的连续生物反应器生产率的影响。 （周期性）强制作用于进料中的底物浓度。为此，评估了实践中常见的一些替代波形，并比较了它们的性能。使用分析/数值方法。初步的分析步骤基于π-crite-rion，它为小幅度提供有用的信息。然后，当需要进行重大改进时，可以通过连续优化过程将其扩展到更大的幅度。发现特定波形的选择会影响过程的性能，并且对于任何过程条件都没有唯一的最佳强迫，但是其选择取决于操作参数以及强迫幅度和频率值。此外，广泛检查了波形函数对冲洗条件的影响。分析表明，在这项工作中检查的所有波形都可能导致相对于稳态操作的非平凡状态的显着扩大。特别地，在实践中，方波强制导致针对任何进料底物浓度和强制参数的明确选择的冲洗条件的消失。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号