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首页> 外文期刊>AJR: American Journal of Roentgenology : Including Diagnostic Radiology, Radiation Oncology, Nuclear Medicine, Ultrasonography and Related Basic Sciences >Feasibility of in vivo MR elastographic splenic stiffness measurements in the assessment of portal hypertension.
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Feasibility of in vivo MR elastographic splenic stiffness measurements in the assessment of portal hypertension.

机译：在门脉高压评估中体内MR弹性成像脾硬度测量的可行性。

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OBJECTIVE: Liver stiffness is associated with portal hypertension in patients with chronic liver disease. However, the relation between spleen stiffness and clinically significant portal hypertension remains unknown. The purposes of this study were to determine the feasibility of measuring spleen stiffness with MR elastography and to prospectively test the technique in healthy volunteers and in patients with compensated liver disease. MATERIALS AND METHODS: Spleen stiffness was measured with MR elastography in 12 healthy volunteers (mean age, 37 years; range, 25-82 years) and 38 patients (mean age, 56 years; range, 36-60 years) with chronic liver disease of various causes. For patients with liver disease, laboratory findings, spleen size, presence and size of esophageal varices, and liver histologic results were recorded. Statistical analyses were performed to assess all measurements. RESULTS: MR elastography of the spleen was successfully performed on all volunteers and patients. The mean spleen stiffness was significantly lower in the volunteers (mean, 3.6 +/- 0.3 kPa) than in the patients with liver fibrosis (mean, 5.6 +/- 5.0 kPa; range, 2.7-19.2 kPa; p < 0.001). In addition, a significant correlation was observed between liver stiffness and spleen stiffness for the entire cohort (r(2) = 0.75; p < 0.001). Predictors of spleen stiffness were splenomegaly, spleen volume, and platelet count. A mean spleen stiffness of 10.5 kPa or greater was identified in all patients with esophageal varices. CONCLUSION: MR elastography of the spleen is feasible and shows promise as a quantitative method for predicting the presence of esophageal varices in patients with advanced hepatic fibrosis.
机译：目的：肝硬化与慢性肝病患者的门脉高压相关。然而，脾脏僵硬与临床上显着的门脉高压之间的关系仍然未知。这项研究的目的是确定使用MR弹性成像技术测量脾脏硬度的可行性，并前瞻性地在健康志愿者和患有代偿性肝病的患者中测试该技术。材料与方法：MR弹性成像技术测量了12名健康志愿者（平均年龄37岁;范围25-82岁）和38例慢性肝病患者（平均年龄56岁;范围36-60岁）的脾脏刚度。各种原因。对于肝病患者，记录实验室检查结果，脾脏大小，食管静脉曲张的存在和大小以及肝脏组织学结果。进行统计分析以评估所有测量。结果：所有志愿者和患者均成功进行了脾脏的MR弹性成像。志愿者的平均脾脏刚度显着低于肝纤维化患者（均值5.6 +/- 5.0 kPa;范围：2.7-19.2 kPa; p <0.001）（均值3.6 +/- 0.3 kPa）。此外，整个队列的肝硬度与脾脏硬度之间存在显着相关性（r（2）= 0.75; p <0.001）。脾脏僵硬的预测指标是脾肿大，脾脏体积和血小板计数。在所有患有食管静脉曲张的患者中，平均脾脏硬度为10.5 kPa或更高。结论：脾脏的MR弹性成像是可行的，并有望作为一种定量方法来预测晚期肝纤维化患者食管静脉曲张的存在。

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