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首页> 外文期刊>Human cell: official journal of Human Cell Research Society >LncRNA HEIH regulates cell proliferation and apoptosis through miR-4458/SOCS1 axis in triple-negative breast cancer
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LncRNA HEIH regulates cell proliferation and apoptosis through miR-4458/SOCS1 axis in triple-negative breast cancer

机译：LNCRNA Heih通过MiR-4458 / SoCS1轴调节细胞增殖和细胞凋亡，在三阴性乳腺癌中

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摘要

Hepatocellular carcinoma up-regulated EZH2-associated long non-coding RNA (HEIH) is a newly discovered lncRNA and has been suggested to be dysregulated in human cancers. However, the role of HEIH in triple-negative breast cancer (TNBC) was still unknown. Thus, the aim of our study was to investigate the clinical significance and biological function of HEIH in TNBC. In our study, we found that HEIH was overexpressed in TNBC tissues and cell lines compared with adjacent normal mammary tissues and normal mammary epithelial cell line, respectively. In addition, we conducted bioinformatic analysis, and found that HEIH harbors a potential miR-4458-binding site. Furthermore, we observed that HEIH and miR-4458 had a high correlation score in TNBC tissues, and HEIH directly binds to miR-4458, and negatively regulates miR-4458 expression in TNBC cells. The in vitro cell proliferation and apoptosis assays suggested down-regulation of HEIH inhibited TNBC cell proliferation and promoted apoptosis through regulating miR-4458/SOCS1 axis. Finally, we found that TNBC patients with tumor size ≥ 5 cm or advanced clinical stage had higher levels of HEIH expression than patients with tumor size < 5 cm or early clinical stage. In conclusion, HEIH functions as an oncogenic lncRNA that is overexpressed in TNBC and associated with clinical progression, and regulates TNBC cell proliferation and apoptosis through miR-4458/SOCS1 axis.
机译：肝细胞癌上调的EzH2相关的长期非编码RNA（HeiH）是一种新发现的LNCRNA，并已建议在人类癌症中进行多重测定。然而，Heih在三重阴性乳腺癌（TNBC）中的作用仍然未知。因此，我们的研究目的是探讨河北河北省河口的临床意义和生物学功能。在我们的研究中，我们发现Heih分别与邻近的正常乳腺组织和正常乳腺上皮细胞系相比在TNBC组织和细胞系中过表达。此外，我们进行了生物信息化分析，发现河流留下了潜在的miR-4458结合位点。此外，我们观察到HeiH和MiR-4458在TNBC组织中具有高相关评分，HeiH与miR-4458直接结合，并负调节TNBC细胞中的miR-4458表达。体外细胞增殖和凋亡测定表明，通过调节miR-4458 / SoCs1轴来抑制河口抑制TNBC细胞增殖和促进细胞凋亡。最后，我们发现肿瘤大小≥5厘米或晚期临床阶段的TNBC患者患有较高水平的Heih表达，而不是肿瘤大小的患者<5cm或早期临床阶段。总之，Heih用作在TNBC中过表达并与临床进展相关的致癌物质，并通过MIR-4458 / SOCS1轴调节TNBC细胞增殖和细胞凋亡。

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