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首页> 外文期刊>Hypertension: An Official Journal of the American Heart Association >Nighttime Blood Pressure Measured by Home Blood Pressure Monitoring as an Independent Predictor of Cardiovascular Events in General Practice: The J-HOP Nocturnal Blood Pressure Study
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Nighttime Blood Pressure Measured by Home Blood Pressure Monitoring as an Independent Predictor of Cardiovascular Events in General Practice: The J-HOP Nocturnal Blood Pressure Study

机译：通过家用血压监测测量的夜间血压作为一般实践中心血管事件的独立预测因子：J跳夜间血压研究

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We developed an innovative automated home blood pressure (BP) monitoring method that measures BP while asleep repeatedly over several days. Our aim was to assess the predictive ability of nighttime BP obtained using the home BP device for incident cardiovascular disease (CVD) in general practice patients. We used data from the nationwide practice-based J-HOP (Japan Morning Surge-Home Blood Pressure) Nocturnal BP Study, which recruited 2545 Japanese with a history of or risk factors for CVD (mean age 63 years; antihypertensive medication use 83%). The associations between nighttime home BPs (measured at 2:00, 3:00, and 4:00 am using validated, automatic, and oscillometric home BP devices) and incident CVD, including coronary disease and stroke events, were assessed with Cox proportional hazards models. The meanSD office, morning home, and nighttime home systolic BP (SBP)/diastolic BP were 140 +/- 15/82 +/- 10, 137 +/- 15/79 +/- 10, and 121 +/- 15/70 +/- 9 mmHg, respectively. During a follow-up of 7.1 +/- 3.8 years (18,116 person-years), 152 CVD events occurred. A 10-mmHg increase of nighttime home SBP was associated with an increased risk of CVD events (hazard ratios [95% CIs]: 1.201 [1.046-1.378]), after adjustments for covariates including office and morning home SBPs. The model fit assessed by the change in Goodness-of-Fit was improved when we added nighttime home SBP into the base models including office and morning home SBPs (6.838 [5.6%]; P=0.009). This is among the first and largest nationwide practice-based study demonstrating that nighttime SBP obtained using a home device is a predictor of incident CVD events, independent of in-office and morning in-home SBP measurement.
机译：我们开发了一种创新的自动化家庭血压（BP）监测方法，衡量BP的速度，在几天内睡着了。我们的目的是评估在一般实践患者中使用家用BP设备获得的夜间BP的预测能力（CVD）。我们使用了来自全国基于实践的J-Hop（日本早晨电涌家庭血压）夜间BP研究的数据，其中招募了2545名日本人的CVD历史或危险因素（平均年龄63岁;抗高血压药物使用83％） 。夜间Home BPS（2:00，3:00和4:00使用验证，自动和示波器家庭BP设备）和事件CVD（包括冠状动脉和中风事件）之间的关联被Cox比例危害评估楷模。 Systolic BP（SBP）/舒张压BP的手工办公室，早上回家和夜间家用收缩型BP（SBP）/舒张压率为140 +/-15 / 82 +/- 10,137 +/-15 / 79 +/- 10和121 +/- 15 /分别为70 +/- 9 mmhg。在7.1 +/- 3.8岁的后续行动期间（18,116人 - 年），发生了152个CVD事件。在调整包括办公室和早上家庭SBP的协调会的调整之后，夜间家庭SBP增加了10 mmHg的夜间家庭SBP（危险比率[95％）：1.201 [1.046-1.378]）。当我们将夜间家庭SBP添加到基础型号时，通过适应性的良好变化评估的模型适合在包括办公室和早上家庭SBP（6.838 [5.6％]; P = 0.009）。这是一项基于全国性的第一和最大的基于全国范围的研究之一，证明使用家庭设备获得的夜间SBP是事件CVD事件的预测因子，独立于办公室和早上在家中的SBP测量。

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