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首页> 外文期刊>Human and Experimental Toxicology >Naringin improves zidovudine- and stavudine-induced skeletal muscle complications in rats
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Naringin improves zidovudine- and stavudine-induced skeletal muscle complications in rats

机译：Naringin改善了大鼠的Zidovudine和Stavudine诱导的骨骼肌并发症

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Chronic use of nucleoside reverse transcriptase inhibitors (NRTIs) in managing human immunodeficiency virus (HIV) infection has been associated with several complications. Available management options for these complications have yielded controversial results, thus the need to urgently find newer alternatives. Naringin, a plant-derived flavonoid, has been shown to possess antioxidant and antiapoptotic properties which can be exploited in managing NRTI-induced complications. This study therefore investigated the effects of naringin on some NRTI-induced complications. Forty-nine rats (200-250 g) were divided into seven groups and were orally treated with stavudine (d4T)-only, d4T + naringin, d4T + vitamin E, zidovudine (AZT)-only, AZT + naringin, AZT + vitamin E, and distilled water, respectively. Drugs were administered once daily for 56 days, and oral glucose tolerance tests conducted on day 54 of the experiments and rats were thereafter sacrificed on day 56 by halothane overdose. Plasma samples and the left gastrocnemius muscles were stored at -80 degrees C for further analysis. There was significant glucose intolerance, insulin resistance, oxidative stress, and apoptosis in the skeletal muscles of AZT- or d4T-only-treated rats. Naringin, however, significantly reduced fasting blood glucose and fasting plasma insulin concentrations, mitigated glucose intolerance, and insulin resistance in addition to reducing malondialdehyde and carbonyl protein concentrations when coadministered with either NRTIs. Furthermore, naringin improved antioxidant enzyme activities, reduced skeletal muscle BCL-2-associated X protein expression, and improved B-cell lymphoma-2 protein expression compared to AZT- or d4T-only-treated rats. Naringin ameliorated AZT- and d4T-induced complications and therefore should be further investigated as a possible nutritional supplement in managing HIV infection.
机译：核苷逆转录酶抑制剂（NRTIS）在管理人类免疫缺陷病毒（HIV）感染中的慢性用途已经与几种并发症有关。这些并发症的可用管理选项已经产生了有争议的结果，因此需要迫切地找到更新的替代品。已经显示出一种植物衍生的类黄酮，具有抗氧化剂和抗污染性质，其可以在管理NRTI诱导的并发症中具有抗氧化剂和抗污染性质。因此，本研究研究了柚皮蛋白对一些NRTI诱导的并发症的影响。将四十九只大鼠（200-250克）分为七组，用史莱达丁（D4T）-Only，D4T + Naringin，D4T +维生素E，Zidovudine（AZT）-Only，AZT + Naringin，AZT +维生素（AZT +维生素）口服治疗E，分别和蒸馏水。每天一次施用药物56天，然后在实验和大鼠的第54天进行的口服葡萄糖耐量试验在第56天通过氟烷过量牺牲。等离子体样品和左胃肠肌肌肉储存在-80℃下进行进一步分析。在AZT或D4T或D4T处理的大鼠的骨骼肌中存在显着的葡萄糖不耐受，胰岛素抵抗，氧化应激和细胞凋亡。然而，除了在用NRTIS共同调用时，除了减少丙二醛和羰基蛋白质浓度之外，露珠葡萄呤显着降低了空腹血糖和空腹胰岛素浓度，减轻葡萄糖不耐受性和胰岛素耐药性。此外，Naringin改善了抗氧化酶活性，降低了骨骼肌Bcl-2相关的X蛋白表达，以及与仅用于AZT或D4T的大鼠相比改善的B细胞淋巴瘤-2蛋白表达。 Naringin改善了AZT和D4T诱导的并发症，因此应进一步调查作为管理HIV感染的可能营养补充剂。

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