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首页> 外文期刊>Human and Experimental Toxicology >Effect on oxidative stress, hepatic chemical metabolizing parameters, and genotoxic damage of mad honey intake in rats
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Effect on oxidative stress, hepatic chemical metabolizing parameters, and genotoxic damage of mad honey intake in rats

机译：对氧化应激，肝化学代谢参数和大鼠疯狂摄入遗传毒性损伤的影响

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A total of 66 male Wistar rats were used and six groups (control: 10 animals and experimental: 12 animals) were formed. While a separate control group was established for each study period, mad honey application to the animals in the experimental group was carried out with a single dose (12.5 g kg(-1) body weight (b.w.); acute stage), at a dose of 7.5 g kg(-1) b.w. for 21 days (subacute stage), and at a dose of 5 g kg(-1) b.w. for 60 days (chronic stage). Tissue and blood oxidative stress markers (malondialdehyde (MDA), nitric oxide (NO), 4-hydroxynonenal (HNE), superoxide dismutase, catalase, glutathione (GSH) peroxidase, and glucose-6-phosphate dehydrogenase), hepatic chemical metabolizing parameters in the liver (cytochrome P450 2E1, nicotinamide adenine dinucleotide (NADH)-cytochrome b5 reductase, nicotinamide adenine dinucleotide phosphate (NADPH)-cytochrome c reductase (CYTC), GSH S-transferase (GST), and GSH), and micronucleus and comet test in some samples were examined. Findings from the study showed that single and repeated doses given over the period increased MDA, NO, and HNE levels while decreasing/increasing tissue and blood antioxidant enzyme activities. From hepatic chemical metabolizing parameters, GST activity increased in the subacute and chronic stages and CYTC activity increased in the acute period, whereas GSH level decreased in the subacute stage. Changes in tail and head intensities were found in most of the comet results. Mad honey caused oxidative stresses for each exposure period and made some significant changes on the comet test in certain periods for some samples obtained. In other words, according to the available research results obtained, careless consumption of mad honey for different medical purposes is not appropriate.
机译：使用总共66只雄性Wistar大鼠，形成了6组（对照：10只动物和实验：12只动物）。虽然为每个研究期间建立了单独的对照组，但在实验组中疯狂的蜂蜜应用用单剂量（12.5g kg（-1）体重（bw）;急性阶段）进行，以剂量进行7.5g kg（-1）bw 21天（亚急性阶段），并且剂量为5g kg（-1）b.w. 60天（长期阶段）。组织和血氧胁迫标记物（丙二醛（MDA），一氧化氮（NO），4-羟基诺（HNE），超氧化物歧化酶，过氧化氢酶，谷胱甘肽（GSH）过氧化物酶和葡萄糖-6-磷酸脱氢酶），肝化学代谢参数肝脏（细胞色素P450 2E1，烟酰胺腺嘌呤二核苷酸（NADH）-CYTOCHROME B5还原酶，烟酰胺腺嘌呤二核苷酸磷酸酯（NADPH） - 胞菌色谱酶（CYTC），GSH S转移酶（GST）和GSH），和微核和彗星试验在一些样品中检查。研究结果表明，在该期间内给出的单一和重复剂量增加MDA，NO和HNE水平，同时降低/增加组织和血液抗氧化酶活性。根据肝化学​​代谢参数，急性期间的亚急性和慢性阶段的GST活性增加，急性时期增加了CYTC活性，而亚急性期间GSH水平降低。在大多数彗星结果中发现了尾部和头部强度的变化。疯狂的蜂蜜引起了每个暴露时间的氧化应激，并在一定时间内对所获得的一些样品进行了一些显着的变化。换句话说，根据可用的研究结果，粗心消费的疯狂蜂蜜的不同医疗目的是不合适的。

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