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首页> 外文期刊>Alcohol >Anti-hepatitis B core positivity as a risk factor for hepatocellular carcinoma in alcoholic cirrhosis: A case-control study
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Anti-hepatitis B core positivity as a risk factor for hepatocellular carcinoma in alcoholic cirrhosis: A case-control study

机译：抗乙型肝炎核心阳性是酒精性肝硬化肝细胞癌的危险因素：病例对照研究

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Hepatocellular carcinoma (HCC) is occasionally developed in patients with alcoholic cirrhosis. Old age, male gender, lifetime quantity of alcohol, and presence of hepatitis C virus (HCV) infection are risk factors for HCC in alcoholic cirrhosis. In this study, we investigated whether anti-hepatitis B core (HBc) positivity or occult hepatitis B virus (HBV) infection is a risk factor for HCC in patients with alcoholic cirrhosis. Between January 2006 and August 2008, a total of 72 cirrhotic male patients with an initial diagnosis of HCC, hospitalized in three major hospitals in the Incheon area, were enrolled as cases. Another 72 cirrhotic male patients without HCC, who matched the cases by age (±3 years), were enrolled as controls. All cases and controls were negative for hepatitis B surface antigen and anti-HCV, but had history of chronic alcohol intake over 80. g per day. The clinical characteristics including presence of anti-HBc or serum HBV DNA (identified by nested polymerase chain reaction) were investigated. The mean age of both the cases and controls was 62 ± 10 years. The basal laboratory data, Child-Pugh scores, total lifetime alcohol intake (1459 ± 1364 versus 1641 ± 1045. kg), and detection rates of serum HBV DNA [31.7% (20/63) versus 29.9% (20/67)] of the cases and controls were not significantly different. However, the anti-HBc positivity rate was higher among the cases [86.1% (62/72)] than in the controls [66.7% (48/72); p= 0.005] and was the only significant risk factor for HCC (odds ratio; 3.1, 95% confidence interval; 1.354-7.098, p= 0.007). Anti-HBc positivity was identified as a risk factor for the development of HCC in patients with alcoholic cirrhosis.
机译：酒精性肝硬化患者偶尔会发生肝细胞癌（HCC）。老年，男性，一生中饮酒的量以及丙型肝炎病毒（HCV）感染的存在是酒精性肝硬化中HCC的危险因素。在这项研究中，我们调查了酒精性肝硬化患者中抗乙型肝炎核心（HBc）阳性或隐性乙型肝炎病毒（HBV）感染是否是HCC的危险因素。在2006年1月至2008年8月之间，共有72例最初诊断为HCC的肝硬化男性患者在仁川地区的三所主要医院住院。纳入另外72例无肝癌的肝硬化男性患者，按年龄（±3岁）相匹配。所有病例和对照的乙型肝炎表面抗原和抗HCV均为阴性，但有慢性酒精摄入量超过每天80 g的病史。研究了包括抗-HBc或血清HBV DNA（通过巢式聚合酶链反应鉴定）的临床特征。病例和对照的平均年龄均为62±10岁。基础实验室数据，Child-Pugh得分，终生饮酒总量（1459±1364对1641±1045. kg）和血清HBV DNA检出率[31.7％（20/63）对29.9％（20/67）]的病例和对照没有显着差异。然而，在这些病例中，抗-HBc阳性率[86.1％（62/72）]高于对照组[66.7％（48/72）]。 p = 0.005]，是肝癌的唯一重要危险因素（赔率; 3.1，95％置信区间; 1.354-7.098，p = 0.007）。抗HBc阳性被确定为酒精性肝硬化患者发展HCC的危险因素。

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