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Prenatal ethanol increases sucrose reinforcement, an effect strengthened by postnatal association of ethanol and sucrose

机译：产前乙醇增加蔗糖的强化作用，产后乙醇和蔗糖的结合会增强这种作用

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Late prenatal exposure to ethanol recruits sensory processing of the drug and of its motivational properties, an experience that leads to heightened ethanol affinity. Recent studies indicate common sensory and neurobiological substrates between this drug and sweet tastants. Using a recently developed operant conditioning technique for infant rats, we examined the effects of prenatal ethanol history upon sucrose self-administration (postnatal days, PDs 14-17). Prior to the last conditioning session, a low (0.5g/kg) or a high (2.5g/kg) ethanol dose were paired with sucrose. The intention was to determine if ethanol would inflate or devalue the reinforcing capability of the tastant and if these effects are dependent upon prenatal ethanol history. Male and female pups prenatally exposed to ethanol (2.0g/kg) responded more when reinforced with sucrose than pups lacking this antenatal experience. Independently of prenatal status, a low ethanol dose (0.5g/kg) enhanced the reinforcing capability of sucrose while the highest dose (2.5g/kg) seemed to ameliorate the motivational properties of the tastant. During extinction (PD 18), two factors were critical in determining persistence of responding despite reinforcement omission. Pups prenatally exposed to ethanol that subsequently experienced the low ethanol dose paired with sucrose, showed higher resistance to extinction. The effects here reported were not associated with differential blood alcohol levels across prenatal treatments. These results indicate that fetal ethanol experience promotes affinity for a natural sweet reinforcer and that low doses of ethanol are also capable of enhancing the positive motivational consequences of sucrose when ethanol and sucrose are paired during infancy.
机译：产前晚期暴露于乙醇会使该药物及其动机特性产生感官加工，这种经历导致乙醇亲和力增强。最近的研究表明该药物与甜味剂之间存在常见的感觉和神经生物学底物。使用最近开发的用于婴儿大鼠的操作性调节技术，我们检查了产前乙醇史对蔗糖自我给药的影响（产后天数，PD 14-17）。在最后一次调理之前，将低剂量（0.5g / kg）或高剂量（2.5g / kg）的乙醇与蔗糖配对。目的是确定乙醇是否会膨胀或降低调味剂的增强能力，以及这些作用是否取决于产前乙醇史。产前暴露于乙醇（2.0g / kg）的雄性和雌性幼犬用蔗糖强化后的反应比缺乏这种产前经历的幼犬要好。与产前状态无关，低乙醇剂量（0.5g / kg）增强了蔗糖的增强能力，而最高剂量（2.5g / kg）似乎改善了促味剂的动力特性。在灭绝期间（PD 18），尽管有遗漏，但两个因素对于确定反应的持久性至关重要。产前暴露于乙醇的幼仔随后经历了低乙醇剂量与蔗糖的配对，表现出更高的灭绝抗性。此处报道的影响与产前治疗期间血液中酒精含量的差异无关。这些结果表明，胎儿乙醇的经历促进了对天然甜味增强剂的亲和力，当婴儿期将乙醇和蔗糖配对时，低剂量的乙醇也能够增强蔗糖的积极动机。

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