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首页> 外文期刊>Alcohol >Decreased white matter integrity in fronto-occipital fasciculus bundles: Relation to visual information processing in alcohol-dependent subjects
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Decreased white matter integrity in fronto-occipital fasciculus bundles: Relation to visual information processing in alcohol-dependent subjects

机译：额枕筋膜束中白质完整性降低：与酒精依赖型受试者的视觉信息处理有关

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Chronic alcohol abuse is characterized by impaired cognitive abilities with a more severe deficit in visual than in verbal functions. Neuropathologically, it is associated with widespread brain structural compromise marked by gray matter shrinkage, ventricular enlargement, and white matter degradation. The present study sought to increase current understanding of the impairment of visual processing abilities in alcohol-dependent subjects, and its correlation with white matter microstructural alterations, using diffusion tensor imaging (DTI). To that end, a DTI study was carried out on 35 alcohol-dependent subjects and 30 healthy male control subjects. Neuropsychological tests were assessed for visual processing skills and deficits were reported as raw dysfunction scores (rDyS). Reduced FA (fractional anisotropy) and increased MD (mean diffusivity) were observed bilaterally in inferior and superior fronto-occipital fasciculus (FOF) fiber bundles. A significant inverse correlation in rDyS and FA values was observed in these fiber tracts whereas a positive correlation of these scores was found with the MD values. Our results suggest that FOF fiber bundles linking the frontal lobe to occipital lobe might be related to visual processing skills. This is the first report of an alteration of the white matter microstructure of FOF fiber bundles that might have functional consequences for visual processing in alcohol-dependent subjects who exhibit no neurological complications.
机译：慢性酒精滥用的特征是认知能力受损，视觉功能比言语功能严重缺陷。在神经病理学上，它与广泛的脑部结构受损有关，其特征是灰质缩小，心室扩大和白质降解。本研究试图通过扩散张量成像（DTI）来增加对酒精依赖型受试者视觉加工能力受损及其与白质微结构改变的相关性的当前了解。为此，对35名酒精依赖者和30名健康男性对照者进行了DTI研究。评估了神经心理学测试的视觉处理能力，缺陷被报告为原始功能障碍评分（rDyS）。在下部和上部额枕筋膜（FOF）纤维束中，双侧观察到FA（分数各向异性）降低和MD（平均扩散率）升高。在这些纤维束中，rDyS和FA值呈显着负相关，而这些分数与MD值呈正相关。我们的研究结果表明，将额叶连接到额叶的FOF纤维束可能与视觉处理技能有关。这是FOF纤维束白质微观结构改变的首次报道，该改变可能对没有神经系统并发症的酒精依赖受试者的视觉加工产生功能性影响。

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