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首页> 外文期刊>Alcohol >Blood ethanol concentration profiles: a comparison between rats and mice.
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Blood ethanol concentration profiles: a comparison between rats and mice.

机译：血液乙醇浓度曲线：大鼠和小鼠之间的比较。

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摘要

It is important to select an appropriate model system for studies examining the mechanisms of ethanol-induced injury. The most common model systems use either mice or rats with ethanol administered by means of intragastric gavage or intraperitoneal injection, yet few studies have compared directly the blood ethanol concentration (BEC) profiles that result from each of these model systems. In the current study, Sprague-Dawley rats and C57BL/6J mice were given ethanol by means of intragastric gavage or intraperitoneal injection at 40 days of age. Blood samples were collected at consistent time intervals to determine BECs. Blood ethanol concentrations in mice were sharper, with a more rapid rise to a sharp peak BEC, followed by a relatively rapid decline. In contrast, rat BEC profiles showed an initial rapid rise, followed by a more gradual rise to peak concentrations, and, then, a relatively gradual decline. This difference was particularly evident in rats receiving ethanol intragastrically. The differences found in BEC profiles between rats and mice and between ethanol administration paradigms may yield differences in the extent or mechanism of damage induced by ethanol, an important consideration when selecting an appropriate model for the investigation of ethanol-induced tissue damage.
机译：选择合适的模型系统来研究乙醇诱导的损伤机制非常重要。最常见的模型系统使用通过胃管法或腹膜内注射方式给乙醇注射的小鼠或大鼠，但很少有研究直接比较由这些模型系统中的每一个产生的血液乙醇浓度（BEC）曲线。在当前的研究中，在40天大时，通过胃管灌胃或腹膜内注射方式给Sprague-Dawley大鼠和C57BL / 6J小鼠喂以乙醇。以一致的时间间隔采集血样以确定BEC。小鼠的血液中乙醇浓度更高，BEC升高更快，达到峰值BEC，随后迅速降低。相反，大鼠BEC曲线显示出最初的快速上升，然后逐渐逐渐上升到峰值浓度，然后相对逐渐下降。这种差异在胃内接受乙醇的大鼠中尤为明显。在大鼠和小鼠之间以及乙醇给药范例之间的BEC谱中发现的差异可能会导致乙醇诱导的损伤程度或机制不同，这是选择合适的模型进行乙醇诱导的组织损伤研究时的重要考虑因素。

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