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首页> 外文期刊>Alcohol >Taste-aversion-prone (TAP) rats and taste-aversion-resistant (TAR) rats differ in ethanol self-administration, but not in ethanol clearance or general consumption.
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Taste-aversion-prone (TAP) rats and taste-aversion-resistant (TAR) rats differ in ethanol self-administration, but not in ethanol clearance or general consumption.

机译：容易产生味觉厌恶（TAP）的大鼠和能抵抗味觉厌恶（TAR）的大鼠在乙醇自我给药方面有所不同，但在乙醇清除率或一般消耗方面没有差异。

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摘要

Taste-aversion (TA)-prone (TAP) rats and TA-resistant (TAR) rats have been developed by means of bidirectional selective breeding on the basis of their behavioral responses to a TA conditioning paradigm. The TA conditioning involved the pairing of an emetic-class agent (cyclophosphamide) with a novel saccharin solution as the conditioned stimulus. Despite the absence of ethanol in the selective breeding process, these rat lines differ widely in ethanol self-administration. In the current study, blood alcohol concentrations (BACs) were determined after 9 days of limited (2 h per day) access to a simultaneous, two-bottle choice of a 10% ethanol in water solution [volume/volume (vol./vol.)] or plain water. The BACs correlated highly with ethanol intake among TAR rats, but an insufficient number of TAP rats yielded measurable BACs to make the same comparison within this rat line. The same rats were subsequently exposed to 24-h access of a two-bottle choice (10% ethanol or plain water) for 8 days. Ethanol consumption during the 24-h access period correlated highly with that seen during limited access. Subsequent TA conditioning with these rats yielded line-typical differences in saccharin preferences. In a separate group of rats, ethanol clearance was determined by measuring BACs at 1, 4, and 7 h after injection of a 2.5-g/kg dose of ethanol. Ethanol clearance was not different between the two lines. Furthermore, the lines did not differ with respect to food and water consumption. Therefore, the TAP rat-TAR rat differences in ethanol consumption cannot be attributed to line differences in ethanol metabolism or in general consummatory behavior. The findings support our contention that the line differences in ethanol consumption are mediated by differences in TA-related mechanisms. The findings are discussed with respect to genetically based differences in the subjective experience of ethanol.
机译：基于对TA条件范式的行为反应，通过双向选择性育种开发了易受味觉（TA）的大鼠和具有TA抵抗性（TAR）的大鼠。 TA调节涉及将催吐类药物（环磷酰胺）与新型糖精溶液配对作为调节刺激。尽管在选择性育种过程中没有乙醇，但是这些大鼠品系在乙醇自我给药方面存在很大差异。在本研究中，血液中酒精浓度（BAC）是在有限的9天（每天2小时）访问同时，两瓶含10％乙醇的水溶液后确定的[体积/体积（vol./vol 。）]或白开水。 BAC与TAR大鼠中的乙醇摄入量高度相关，但是TAP大鼠的数量不足，无法测量出BAC，因此无法在该大鼠品系中进行相同的比较。随后将相同的大鼠暴露于两瓶选择（10％乙醇或清水）的24小时内接触8天。在24小时访问期间的乙醇消耗与有限访问期间的乙醇消耗高度相关。随后用这些大鼠进行的TA调理产生了糖精偏好的线型差异。在另一组大鼠中，通过在注射2.5 g / kg剂量的乙醇后1、4和7小时测量BAC来确定乙醇清除率。两条线之间的乙醇清除率没有差异。此外，就食物和水的消费而言，界线没有差异。因此，TAP大鼠-TAR大鼠乙醇消费量的差异不能归因于乙醇代谢或一般消费行为的差异。这些发现支持了我们的观点，即乙醇消耗量的差异是由TA相关机制的差异介导的。关于乙醇主观经验中基于遗传的差异讨论了该发现。

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