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首页> 外文期刊>Alcohol >Effect of ethanol on 24-hour hormonal changes in peripubertal male rats.
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Effect of ethanol on 24-hour hormonal changes in peripubertal male rats.

机译：乙醇对青春期雄性大鼠24小时激素变化的影响。

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We analyzed the effect of chronic (4 weeks) ethanol feeding on 24-h variation of pituitary-testicular function in peripubertal male Wistar rats by measuring circulating concentrations of prolactin, follicle-stimulating hormone, luteinizing hormone, testosterone, and thyrotropin. Animals were maintained under a 12-h light: 12-h dark photoperiod and received a liquid diet for 4 weeks, starting on day 35 of life. The ethanol-fed group received a diet similar to that provided to control animals, except that maltose was replaced isocalorically with ethanol. Ethanol replacement provided 36% of the total caloric content of the diet. Rats were killed at one of six times around the clock, beginning at zeitgeber time (ZT) 1 (ZT 0 = lights on). In ethanol-fed rats globally, secretion of prolactin was augmented, whereas secretion of follicle-stimulating hormone, luteinizing hormone, testosterone, and thyrotropin was decreased. Significant changes in the 24-h secretory pattern of circulating hormones occurred in rats receiving ethanol, including the appearance of two peaks (at ZT 1 and ZT 9), rather than one peak, of follicle-stimulating hormone during the inactive phase of the daily cycle, suppression of the maximum plasma luteinizing hormone concentration during the first part of the inactive phase, and appearance of a second peak of testosterone and prolactin during the second part of the inactive phase (at ZT 5 and ZT 9, respectively) and of a second peak of plasma thyrotropin during the first part of the active phase (at ZT 13). The significant positive correlation between testosterone and individual luteinizing hormone and prolactin concentrations in control animals was no longer observed after ethanol administration. Chronic ethanol administration presumably affects the endogenous clock that modulates the circadian variation of the pituitary-gonadal axis and thyrotropin release in growing male rats.
机译：我们通过测量泌乳素，促卵泡激素，促黄体生成激素，睾丸激素和促甲状腺激素的循环浓度，分析了长期（4周）乙醇喂养对青春期雄性Wistar大鼠垂体-睾丸功能24小时变化的影响。从生命的第35天开始，将动物维持在12小时的光照：12小时的黑暗光周期中，并接受流质饮食4周。用乙醇喂养的组的饮食与对照动物相似，只是麦芽糖等量地被乙醇替代。乙醇替代提供了饮食中总热量的36％。从Zeitgeber时间（ZT）1（ZT 0 =点亮）开始，全天六次杀死大鼠。在全球以乙醇喂养的大鼠中，催乳激素的分泌增加，而促卵泡激素，促黄体生成激素，睾丸激素和促甲状腺激素的分泌减少。在接受乙醇的大鼠中，循环激素的24小时分泌模式发生了显着变化，包括在每天的非活动期出现两个峰值（在ZT 1和ZT 9处）而不是一个峰值的促卵泡激素。周期，在非活动期第一阶段抑制最大的血浆黄体生成激素浓度，以及在非活动期第二阶段（分别在ZT 5和ZT 9）和第二阶段出现睾丸激素和催乳激素的第二个峰值。在活动阶段的第一阶段（在ZT 13时）血浆促甲状腺激素的第二个峰值。服用乙醇后，在对照动物中不再观察到睾丸激素与个体黄体生成激素和催乳素浓度之间的显着正相关。长期服用乙醇可能会影响内源性时钟，该时钟调节成年雄性大鼠垂体-性腺轴的昼夜节律变化和促甲状腺激素的释放。

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