...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Alcohol >Cardiac structure and function after short-term ethanol consumption in rats.
【24h】

Cardiac structure and function after short-term ethanol consumption in rats.

机译：大鼠短期乙醇摄入后的心脏结构和功能。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Using an animal model of alcoholism, we investigated whether 4 months of ethanol consumption was associated with a preclinical stage of alcoholic cardiomyopathy (ACM), as well as activation of the renin-angiotensin system and natriuretic peptides (NPs). In other forms of cardiovascular disease, the latter peptide systems have been used as markers of left ventricular (LV) remodeling and dysfunction. Rats were fed either a liquid ethanol or control diet, and serial blood samples were collected at baseline, as well as at 2 and 4 months, for plasma renin activity (PRA), angiotensin II (ANG II), atrial natriuretic peptide (ANP), and brain natriuretic peptide (BNP) levels. Serial echocardiography (echo) was performed at the same time points, and isolated heart studies were performed to assess ex vivo contractility at 4 months. In both groups at 4 months, there were significant and similar increases in end-diastolic and end-systolic echo dimensions and LV mass. At 4 months, however, a significant decrease wasfound in the relative wall thickness in the ethanol-fed group compared with findings for the control group. In both groups at 4 months, significant and similar time-dependent decreases were shown in BNP and ANP levels compared with baseline values. No differences were found in NP gene expression or tissue levels. In both groups at 4 months, significant and similar increases were found in ANG II levels compared with baseline values. Over time, in both groups, PRA levels were unchanged. In this study, the only cardiac structural feature characteristic of a preclinical ACM was a decrease in relative wall thickness.
机译：使用酒精中毒的动物模型，我们调查了4个月的乙醇摄入是否与酒精性心肌病（ACM）的临床前阶段以及肾素-血管紧张素系统和利钠肽（NP）的激活有关。在其他形式的心血管疾病中，后者的肽系统已用作左心室重构和功能障碍的标志物。给大鼠喂以液态乙醇或对照饮食，并在基线以及第2和第4个月收集一系列血样，用于血浆肾素活性（PRA），血管紧张素II（ANG II），心钠素（ANP） ，以及脑钠肽（BNP）的水平。在同一时间点进行连续超声心动图检查（超声），并进行离体心脏研究以评估4个月时的离体收缩力。两组在四个月时，舒张末期和收缩末期回声的大小以及左室重量都有明显的相似增加。然而，在4个月时，与对照组相比，乙醇喂养组的相对壁厚显着降低。两组在四个月时，与基线值相比，BNP和ANP水平均显示出明显且相似的时间依赖性下降。在NP基因表达或组织水平上未发现差异。两组在第4个月时，与基线值相比，ANG II水平均有显着且相似的升高。随着时间的推移，两组的PRA水平均保持不变。在这项研究中，临床前ACM唯一的心脏结构特征是相对壁厚的减小。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号