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首页> 外文期刊>Alcohol >Correlation between drugs of abuse and alcohol by hair analysis: parents at risk for having children with fetal alcohol spectrum disorder.
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Correlation between drugs of abuse and alcohol by hair analysis: parents at risk for having children with fetal alcohol spectrum disorder.

机译：通过头发分析，滥用药物与酒精之间的相关性：父母有生育胎儿酒精谱系障碍儿童的风险。

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The fatty acid ethyl esters (FAEEs) hair test, a biomarker of excessive alcohol exposure, has demonstrated its potential for use in fetal alcohol spectrum disorder (FASD) diagnosis. FASD may be compounded by polydrug exposure. Our objective was to determine the likelihood of positive FAEE test among parents testing positive for other drugs of abuse. Samples submitted for FAEE hair analysis by Children's Aid Societies between October 2005 and May 2007, also concurrently tested for cocaine, cannabinoids, opiates, methamphetamine, amphetamine, benzodiazepines, methadone, and/or oxycodone, were included in our analysis. Subjects consisted of parents suspected of using excessive amounts of alcohol. Parents testing positive for drugs of abuse had a significantly increased risk for testing positive for high FAEE. Mothers testing positive for heavy chronic alcohol use were found to have a threefold increased risk of testing positive for cocaine (odds ratio=3.26, 1.1-9.7). Our results suggest that parents abusing stimulants are at risk of high alcohol exposure, which put their unborn children at risk for FASD.
机译：脂肪酸乙酯（FAEEs）头发测试是酒精过度暴露的生物标志，已证明其可用于胎儿酒精光谱异常（FASD）诊断。 FASD可能由于多药暴露而加重。我们的目标是确定在对其他滥用药物测试呈阳性的父母中，FAEE测试呈阳性的可能性。 2005年10月至2007年5月，由儿童救助协会提交进行FAEE头发分析的样品，还同时进行了可卡因，大麻素，阿片类药物，甲基苯丙胺，苯丙胺，苯并二氮杂卓，美沙酮和/或羟考酮的测试。受试者由怀疑使用过量酒精的父母组成。父母对滥用药物测试呈阳性，高FAEE测试呈阳性的风险显着增加。发现长期大量饮酒呈阳性的母亲可卡因呈阳性的风险增加了三倍（优势比= 3.26，1.1-9.7）。我们的结果表明，滥用兴奋剂的父母有高酒精暴露的风险，这使未出生的孩子有FASD的风险。

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