...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Alcohol >Distribution of ADH1B, ALDH2, CYP2E1 *6, and CYP2E1 *7B genotypes in Turkish population.
【24h】

Distribution of ADH1B, ALDH2, CYP2E1 *6, and CYP2E1 *7B genotypes in Turkish population.

机译：ADH1B，ALDH2，CYP2E1 * 6和CYP2E1 * 7B基因型在土耳其人群中的分布。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The most well-known metabolic pathways from ethanol to acetaldehyde include alcohol dehydrogenase (ADH) and the microsomal ethanol oxidizing system that involves cytochrome P450 2E1 (CYP2E1). Acetaldehyde is further oxidized to acetate by aldehyde dehydrogenase (ALDH). The genetic variation of ADH1B, ALDH2, and CYP2E1 is different among racial populations and cause difference in elimination rates of alcohol. The aim of this study was to determine the polymorphisms of ADH1B (rs1229984; Arg47His), ALDH2 (rs671; Glu487Lys), CYP2E1*6 (rs6413432; T7632A), and CYP2E1*7B (rs6413420; G-71T) in unrelated healthy Turkish population and compare it with other populations. ADH1B and ALDH2 polymorphisms were analyzed with an allele-specific polymerase chain reaction (PCR) assay, and CYP2E1*6 and CYP2E1*7B polymorphisms were genotyped by PCR-restriction fragment length polymorphism method. ADH1B polymorphism analysis yielded the genotype distribution as 83.9% ADH1B*1/1 and 16.1% ADH1B*1/2, and no individuals with ALDH2*1/2 and ALDH2*2/2 genotypes were found in Turkish population. The genotype frequencies for CYP2E1*6 polymorphism were found as 85.3% for homozygote common, 14.1% for heterozygote, and 0.6% for homozygote uncommon. For CYP2E1*7B polymorphism, the genotype frequencies were determined to be 86.5% G/G, 13.5% for G/T; however, no individuals with homozygote uncommon genotype were detected. According to our study results, the genotype distributions of ADH1B, ALDH2, CYP2E1*6, and CYP2E1*7B in Turkish population were similar compared with Caucasian and some European populations, whereas differed significantly from East Asian populations. This study may be useful in epidemiological studies of the influence of ADH1B, ALDH2, CYP2E1*6, and CYP2E1*7B polymorphisms on diseases, including several types of cancer related to alcohol consumption and alcohol dependence.
机译：从乙醇到乙醛的最著名的代谢途径包括乙醇脱氢酶（ADH）和涉及​​细胞色素P450 2E1（CYP2E1）的微粒体乙醇氧化系统。乙醛被醛脱氢酶（ALDH）进一步氧化为乙酸盐。 ADH1B，ALDH2和CYP2E1的遗传变异在不同种族人群之间不同，并且导致酒精清除率的差异。这项研究的目的是确定土耳其健康人群中ADH1B（rs1229984; Arg47His），ALDH2（rs671; Glu487Lys），CYP2E1 * 6（rs6413432; T7632A）和CYP2E1 * 7B（rs6413420; G-71T）的多态性。并与其他人群进行比较。使用等位基因特异性聚合酶链反应（PCR）分析分析ADH1B和ALDH2多态性，并通过PCR限制性片段长度多态性方法对CYP2E1 * 6和CYP2E1 * 7B多态性进行基因分型。 ADH1B多态性分析得出的基因型分布为83.9％ADH1B * 1/1和16.1％ADH1B * 1/2，在土耳其人口中未发现具有ALDH2 * 1/2和ALDH2 * 2/2基因型的个体。发现CYP2E1 * 6多态性的基因型频率常见的纯合子为85.3％，杂合子为14.1％，纯合子为0.6％。对于CYP2E1 * 7B多态性，基因型频率确定为86.5％G / G，13.5％G / T;但是，没有检测到纯合子基因型不常见的个体。根据我们的研究结果，土耳其人群中ADH1B，ALDH2，CYP2E1 * 6和CYP2E1 * 7B的基因型分布与白种人和一些欧洲人群相似，而与东亚人群则有显着差异。这项研究可能在ADH1B，ALDH2，CYP2E1 * 6和CYP2E1 * 7B多态性对疾病的影响的流行病学研究中有用，包括与饮酒和酒精依赖相关的几种癌症。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号