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首页> 外文期刊>Alcohol >Early onset alcohol dependence with high density of family history is not 'male limited'.
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Early onset alcohol dependence with high density of family history is not 'male limited'.

机译：具有高家族史密度的早期发作的酒精依赖不是“男性有限的”。

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OBJECTIVE: Based on classical adoption studies, early onset type II alcoholism was originally described as "male limited." We examined the possible expression of this subtype in present day alcohol-dependent women. Detailed systematic assessment was obtained from 200 treatment-seeking alcohol-dependent women and 189 healthy population controls. Women fulfilling type II alcoholism criteria had higher alcoholism severity as measured by The Alcohol Use Disorders Identification Test and markedly higher use of illicit drugs. Both alcoholism subtypes scored higher than normal on anxiety and impulsivity traits, but type II women scored markedly higher on aggression subscales than either of the other groups. Importantly, density of family history was markedly higher in type II women, suggesting a higher heritability. Despite its original description as male limited, early onset alcoholism with high density of family history is likely to be a valid construct in women. Its recognition has important implications for diagnosis, treatment, and research.
机译：目的：根据经典收养研究，早期发作的II型酒精中毒最初被描述为“男性受限”。我们研究了这种亚型在当今酒精依赖型女性中的可能表达。从200名寻求治疗的酒精依赖妇女和189名健康人群对照中获得了详细的系统评估。符合II型酒精中毒标准的女性，根据《酒精使用障碍识别测试》测得的酒精中毒严重程度较高，非法药物的使用率也明显较高。两种酒精中毒亚型在焦虑和冲动特征方面得分均高于正常水平，但II型女性在侵略性分量表上得分明显高于其他两组。重要的是，II型妇女的家族史密度显着较高，表明遗传力较高。尽管最初将其描述为男性有限，但家族病史密集的早期酒精中毒很可能是女性的有效构造。它的识别对于诊断，治疗和研究具有重要意义。

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