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首页> 外文期刊>Alcohol >Serotonin-3 receptors in the posterior ventral tegmental area regulate ethanol self-administration of alcohol-preferring (P) rats.
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Serotonin-3 receptors in the posterior ventral tegmental area regulate ethanol self-administration of alcohol-preferring (P) rats.

机译：腹侧后方被盖区的血清素3受体调节酒精偏好（P）大鼠的乙醇自我给药。

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Several studies indicated the involvement of serotonin-3 ([5-hydroxy tryptamine] 5-HT(3)) receptors in regulating alcohol-drinking behavior. The objective of this study was to determine the involvement of 5-HT(3) receptors within the ventral tegmental area (VTA) in regulating ethanol self-administration by alcohol-preferring (P) rats. Standard two-lever operant chambers (Coulbourn Instruments, Allentown, PA) were used to examine the effects of seven consecutive bilateral microinfusions of ICS 205-930 (ICS), a 5-HT(3) receptor antagonist, directly into the posterior VTA on the acquisition and maintenance of 15% (vol/vol) ethanol self-administration. P rats readily acquired ethanol self-administration by the fourth session. The three highest doses (0.125, 0.25, and 1.25 microg) of ICS prevented acquisition of ethanol self-administration. During the acquisition postinjection period, all rats treated with ICS demonstrated higher responding on the ethanol lever, with the highest dose producing the greatest effect. In contrast, during the maintenance phase, the three highest doses (0.75, 1.0, and 1.25 microg) of ICS significantly increased responding on the ethanol lever; after the 7-day dosing regimen, responding on the ethanol lever returned to control levels. Microinfusion of ICS into the posterior VTA did not alter the low responding on the water lever and did not alter saccharin (0.0125% wt/v) self-administration. Microinfusion of ICS into the anterior VTA did not alter ethanol self-administration. Overall, the results of this study suggest that 5-HT(3) receptors in the posterior VTA of the P rat may be involved in regulating ethanol self-administration. In addition, chronic operant ethanol self-administration and/or repeated treatments with a 5-HT(3) receptor antagonist may alter neuronal circuitry within the posterior VTA.
机译：几项研究表明5-羟色胺3（[5-羟基色胺] 5-HT（3））受体参与调节饮酒行为。这项研究的目的是确定在腹侧被盖区（VTA）中5-HT（3）受体参与乙醇优先（P）大鼠乙醇自我给药的调节。使用标准的两杆手术室（Coulbourn Instruments，Allentown，PA）检查了连续5次直接向后VTA输注5-HT（3）受体拮抗剂ICS 205-930（ICS）的两次双边双边输注的效果。 15％（体积/体积）乙醇自我管理的获取和维护。到第四节，P大鼠很容易获得乙醇的自我管理。 ICS的三种最高剂量（0.125、0.25和1.25微克）阻止了乙醇的自我给药。在注射后的采集期中，所有接受ICS治疗的大鼠均表现出对乙醇杠杆的更高响应，最高剂量产生最大作用。相反，在维持阶段，ICS的三种最高剂量（0.75、1.0和1.25微克）对乙醇杠杆的响应显着增加;在为期7天的给药方案后，对乙醇杠杆的响应恢复到控制水平。将ICS微量注入后VTA不会改变水杠杆的低响应性，也不会改变糖精（0.0125％wt / v）的自我给药。将ICS微量注入前VTA不会改变乙醇的自我给药。总体而言，这项研究的结果表明，P大鼠后VTA中的5-HT（3）受体可能参与调节乙醇的自我给药。此外，慢性手术乙醇的自我管理和/或5-HT（3）受体拮抗剂的重复治疗可能会改变后VTA内的神经元回路。

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