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首页> 外文期刊>Alcohol >Effects of prolonged ethanol vapor exposure on forced swim behavior, and neuropeptide Y and corticotropin-releasing factor levels in rat brains.
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Effects of prolonged ethanol vapor exposure on forced swim behavior, and neuropeptide Y and corticotropin-releasing factor levels in rat brains.

机译：长时间乙醇蒸气暴露对强迫游泳行为以及大鼠脑中神经肽Y和促肾上腺皮质激素释放因子水平的影响。

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Depressive symptoms in alcohol-dependent individuals are well-recognized and clinically relevant phenomena. The etiology has not been elucidated although it is clear that the depressive symptoms may be alcohol independent or alcohol induced. To contribute to the understanding of the neurobiology of chronic ethanol use, we investigated the effects of chronic intermittent ethanol vapor exposure on behaviors in the forced swim test (FST) and neuropeptide Y (NPY) and corticotropin-releasing factor (CRF) levels in specific brain regions. Adult male Wistar rats were subjected to intermittent ethanol vapor (14 h on/10 h off) or air exposure for 2 weeks and were then tested at three time points corresponding to acute withdrawal (8-12 h into withdrawal) and protracted withdrawal (30 and 60 days of withdrawal) in the FST. The behaviors that were measured in the five-min FST consisted of latency to immobility, swim time, immobility time, and climbing time. The FST results showed that the vapor-exposed animals displayed depressive-like behaviors; for instance, decreased latency to immobility in acute withdrawal and decreased latency to immobility, decreased swim time and increased immobility time in protracted withdrawal, with differences between air- and vapor-exposed animals becoming more pronounced over the 60-day withdrawal period. NPY levels in the frontal cortex of the vapor-exposed animals were decreased compared with the control animals, and CRF levels in the amygdala were correlated with increased immobility time. Thus, extended ethanol vapor exposure produced long-lasting changes in FST behavior and NPY levels in the brain.
机译：酒精依赖者的抑郁症状是公认的临床相关现象。尽管很明显，抑郁症的症状可能是不依赖酒精或酒精引起的，但病因尚未阐明。为了有助于理解慢性乙醇使用的神经生物学，我们研究了慢性间歇性乙醇蒸气暴露对强迫游泳试验（FST）和神经肽Y（NPY）和促肾上腺皮质激素释放因子（CRF）水平在特定行为下的行为的影响。脑区。对成年雄性Wistar大鼠进行间歇性乙醇蒸气（开14小时/ 10小时）或空气暴露2周，然后在三个时间点进行测试，分别对应于急性停药（停药8-12小时）和长时间停药（30次）和退出的60天）。在五分钟FST中测量的行为包括不动潜伏期，游泳时间，不动动时间和爬升时间。 FST结果表明，暴露于蒸气中的动物表现出抑郁样行为。例如，急性停药时减少了动静的潜伏期，而停滞期延长了，减少了游泳动静时间，增加了动静时间，在60天的停药期内，暴露于空气和蒸气的动物之间的差异变得更加明显。与对照动物相比，暴露于蒸气的动物额叶皮质中的NPY水平降低，杏仁核中的CRF水平与固定时间的增加相关。因此，延长的乙醇蒸气暴露会在大脑中产生FST行为和NPY水平的持久变化。

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