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首页> 外文期刊>Alcohol >Place conditioning with ethanol in rats bred for high (UChB) and low (UChA) voluntary alcohol drinking
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Place conditioning with ethanol in rats bred for high (UChB) and low (UChA) voluntary alcohol drinking

机译：将酒精调适成高（UChB）和低（UChA）自愿饮酒的大鼠

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The main goal of this study was to investigate the ability of an ethanol dose (1. g/kg) administered intraperitoneally to induce conditioned place preference (CPP) and/or conditioned place aversion (CPA) in two lines of rats selectively bred for their high (UChB) or low (UChA) voluntary ethanol intake. It was found that five pairings with ethanol induced CPA in ethanol-na?ve rats of both lines, but the magnitude of avoidance was lower in the UChB relative to the UChA rats, indicating that ethanol was less aversive to na?ve rats bred for high alcohol drinking. After 2 months of high voluntary ethanol drinking (～6-7. g/kg/day), in free choice between 10% ethanol and water, ethanol produced CPP in UChB rats, reflecting that ethanol had become rewarding to these rats. By contrast, the low voluntary ethanol intake (<1. g/kg/day) displayed by UChA rats preexposed for 2 months in free choice did not change ethanol-induced CPA. However, preexposure of UChA rats to forced ethanol drinking (～5.7. g/kg/day) and the later inhibition of ethanol-derived acetaldehyde by 4-methylpyrazole (10. mg/kg intraperitoneal), an inhibitor of the enzyme alcohol dehydrogenase, not only increased their voluntary ethanol intake in free choice, but also had a facilitating effect on the development of CPP. Taken together, these results show that the expression of the reinforcing effects of ethanol required a period of voluntary ethanol intake in UChB rats, whereas in UChA rats, both prior exposure to forced ethanol drinking and reduction of high blood ethanol-derived acetaldehyde were required.
机译：这项研究的主要目的是研究经腹膜内给药的乙醇剂量（1. g / kg）在选择性繁殖的两系大鼠中诱导条件性位置偏爱（CPP）和/或条件性位置厌恶（CPA）的能力。高（UChB）或低（UChA）自愿摄入乙醇。研究发现，与乙醇配对的五对大鼠均在两株未用过乙醇的幼年大鼠中产生了CPA，但相对于UChA而言，UChB中回避的程度较低，这表明乙醇对未进食过UC的幼年大鼠的厌恶程度较低。高度饮酒。在自愿性饮酒2个月后（约6-7。g / kg /天），在10％乙醇和水之间自由选择时，乙醇在UChB大鼠中产生CPP，表明乙醇已成为这些大鼠的奖励。相比之下，自由选择预先暴露2个月的UChA大鼠表现出的低自愿乙醇摄入量（<1 g / kg /天）不会改变乙醇诱导的CPA。但是，UChA大鼠预先暴露于强迫饮酒（〜5.7。g / kg /天），后来被4-甲基吡唑（10. mg / kg腹膜内）（一种乙醇脱氢酶抑制剂）抑制了乙醇衍生的乙醛，不仅可以自由选择自愿增加乙醇的摄入量，而且对CPP的发展也有促进作用。综上所述，这些结果表明，在UChB大鼠中，乙醇增强作用的表达需要一段自愿摄入乙醇的时间，而在UChA大鼠中，既需要事先暴露于强制性饮酒，又需要减少高血乙醇衍生的乙醛。

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