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Effect of dissolved oxygen in alcoholic beverages and drinking water on alcohol elimination in humans

机译：酒精饮料和饮用水中的溶解氧对人体消除酒精的影响

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Oxygen plays an important role in the metabolism of alcohol. An increased dissolved oxygen level in alcoholic beverages reportedly accelerates the elimination of alcohol. Therefore, we evaluated the effect of dissolved oxygen in alcohol and the supportive effect of oxygenated water on alcohol pharmacokinetics after the excessive consumption of alcohol, i.e., 540 ml of 19.5% alcohol (v/v). Fifteen healthy males were included in this randomized, 3 × 3 crossover study. Three combinations were tested: X, normal alcoholic beverage and normal water; Y, oxygenated alcoholic beverage and normal water; Z, oxygenated alcoholic beverage and oxygenated water. Blood alcohol concentrations (BACs) were determined by conversion of breath alcohol concentrations. Four pharmacokinetic parameters (Cmax, Tmax, Kel, and AUCall) were obtained using non-compartmental analysis and the times to reach 0.05% and 0.03% BAC (T0.05% and T0.03%) were compared using one-way analysis of variance (ANOVA) and Duncan's post hoc test. With combination Z, the BAC decreased to 0.05% significantly faster (p 0.05) than with combination X. Analyzing the pharmacokinetic parameters, the mean Kel was significantly higher for combination Z than for combinations X and Y (p 0.05), whereas the mean values of Cmax, Tmax and AUCall did not differ significantly among the combinations. Dissolved oxygen in drinks accelerates the decrease in BAC after consuming a large amount of alcohol. However, the oxygen dissolved in the alcoholic beverage alone did not have a sufficient effect in this case. We postulate that highly oxygenated water augments the effect of oxygen in the alcoholic beverage in alcohol elimination. Therefore, it is necessary to investigate the supportive effect of ingesting additional oxygenated water after heavy drinking of normal alcoholic beverages.
机译：氧气在酒精的代谢中起着重要的作用。据报道，酒精饮料中溶解氧含量的增加促进了酒精的消除。因此，我们评估了过量摄入酒精（即540 ml的19.5％酒精（v / v））后，酒精中溶解氧的影响以及含氧水对酒精药代动力学的支持作用。这项随机的3×3交叉研究包括15名健康男性。测试了三种组合：X，普通酒精饮料和普通水; Y，含氧酒精饮料和普通水; Z，含氧酒精饮料和含氧水。血液酒精浓度（BAC）通过呼吸酒精浓度的转换来确定。使用非房室分析获得四个药代动力学参数（Cmax，Tmax，Kel和AUCall），并通过单向分析比较达到BAC 0.05％和0.03％的时间（T0.05％和T0.03％）。方差（ANOVA）和邓肯事后检验。与组合X相比，组合Z的BAC下降至0.05％的速度显着更快（p <0.05）。分析药代动力学参数，组合Z的平均Kel显着高于组合X和Y的平均Kel（p <0.05）。在组合之间，Cmax，Tmax和AUCall的平均值无显着差异。饮用大量酒精后，饮料中的溶解氧会加速BAC的降低。但是，在这种情况下，仅溶解在含酒精的饮料中的氧不能发挥充分的作用。我们假设高度氧化的水会增强酒精饮料中消除氧气中氧气的作用。因此，有必要研究在大量饮用普通酒精饮料后摄入其他含氧水的支持作用。

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