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Effects of low-level alcohol use on cognitive interference: An fMRI study in young adults

机译：低度饮酒对认知干扰的影响：一项针对年轻成年人的功能磁共振成像研究

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摘要

Alcohol consumption is widely known to adversely affect human health. Its neuropathology is largely evident in the cerebellum and frontal lobes, particularly in the immature brains of adolescents and young adults. It may also have a long-lasting impact on executive functioning. The Ottawa Prenatal Prospective Study (OPPS) has followed participants over 20 years, from birth to young adulthood, and has collected data on potentially confounding lifestyle variables, such as prenatal drug exposure and current drug use. The present study investigated the neural activity of 29 young adults from the OPPS using fMRI. The main objective was to discover the impact of regular low-level alcohol consumption on the cognitive interference of these participants, as they performed a Counting Stroop task. Results indicated that, despite a lack of performance differences, young adults who use alcohol on a regular basis differ significantly from non-users with respect to their neural activity as they perform this task. Areas that were significantly more activated in users compared to non-users included the cerebellum, thalamus, fusiform gyrus, prefrontal cortex, and precuneus. The observed activity suggests a significant impact of early alcohol use on neurocognitive functioning despite relatively low levels of alcohol consumption. (C) 2015 Elsevier Inc. All rights reserved.
机译：众所周知，饮酒会对人体健康产生不利影响。它的神经病理学在小脑和额叶，尤其是在青少年和年轻人的大脑中尤为明显。它也可能对执行职能产生长期影响。渥太华产前前瞻性研究（OPPS）对参与者进行了20多年的研究，从出生到成年，并收集了有关可能令人混淆的生活方式变量的数据，例如产前药物暴露和目前的药物使用情况。本研究使用功能磁共振成像研究了来自OPPS的29位年轻人的神经活动。主要目的是发现经常性的低度饮酒对这些参与者执行计数Stroop任务时的认知干扰的影响。结果表明，尽管没有性能差异，但定期饮酒的年轻人在执行这项任务时神经活动与非使用者明显不同。与未使用者相比，使用者中激活程度更高的区域包括小脑，丘脑，梭形回，前额叶皮层和前突。观察到的活动表明，尽管饮酒水平相对较低，但早期饮酒对神经认知功能有重大影响。 （C）2015 Elsevier Inc.保留所有权利。

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