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首页> 外文期刊>Magnetic resonance imaging: An International journal of basic research and clinical applications >Investigating and reducing the effects of confounding factors for robust T-1 and T-2 mapping with cardiac MR fingerprinting
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Investigating and reducing the effects of confounding factors for robust T-1 and T-2 mapping with cardiac MR fingerprinting

机译：用心肌指纹识别调查和减少鲁棒T-1和T-2测绘的混淆因子的影响

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This study aims to improve the accuracy and consistency of T-1 and T-2 measurements using cardiac MR Fingerprinting (cMRF) by investigating and accounting for the effects of confounding factors including slice profile, inversion and T-2 preparation pulse efficiency, and B1+ The goal is to understand how measurements with different pulse sequences are affected by these factors. This can be used to determine which factors must be taken into account for accurate measurements, and which may be mitigated by the selection of an appropriate pulse sequence. Simulations were performed using a numerical cardiac phantom to assess the accuracy of over 600 cMRF sequences with different flip angles, TRs, and preparation pulses. A subset of sequences, including one with the lowest errors in T-1 and T-2 maps, was used in subsequent analyses. Errors due to non-ideal slice profile, preparation pulse efficiency, and B1+ were quantified in Bloch simulations.-Corrections for these effects were included in the dictionary generation and demonstrated in phantom and in vivo cardiac imaging at 3T. Neglecting to model slice profile and preparation pulse efficiency led to underestimated T-1 and overestimated T-2 for most cMRF sequences. Sequences with smaller maximum flip angles were less affected by slice profile and B1+. Simulating all corrections in the dictionary improved the accuracy of T-1 and T-2 phantom measurements, regardless of acquisition pattern. More consistent myocardial T-1 and T-2 values were measured using different sequences after corrections. Based on these results, a pulse sequence which is minimally affected by confounding factors can be selected, and the appropriate residual corrections included for robust T-1 and T-2 mapping.
机译：本研究旨在通过调查和算解包括切片剖面，反演和T-2准备脉冲效率和B1 +的混淆因子的影响，提高使用心MR指纹识别（CMRF）的T-1和T-2测量的准确性和一致性。目标是了解如何对不同脉冲序列的测量受这些因素的影响。这可用于确定必须考虑哪些因素以进行准确测量，并且可以通过选择适当的脉冲序列来减轻。使用数值心脏幻影进行模拟，以评估具有不同翻转角，TRS和制备脉冲的600多个CMRF序列的准确性。在随后的分析中使用包括T-1和T-2映射中最低误差的序列子集。在Bloch模拟中量化了由于非理想切片剖面，准备脉冲效率和B1 +的误差。 - 这些效果的校正包括在字典中的校正，并在3T的体内和体内心脏成像中展示。忽略模型切片型材和制备脉冲效率导致大多数CMRF序列的T-1和高估T-2低估。较小的翻转角度的序列受切片剖面和B1 +的影响较小。无论采集模式如何，模拟词典中的所有校正都提高了T-1和T-2幻像测量的准确性。在校正后使用不同的序列测量更一致的心肌T-1和T-2值。基于这些结果，可以选择通过混淆因子影响的脉冲序列，并且包括用于鲁棒T-1和T-2映射的适当的残余校正。

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