...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Alcohol >BDNF Val66Met and reward-related brain function in adolescents: Role for early alcohol consumption
【24h】

BDNF Val66Met and reward-related brain function in adolescents: Role for early alcohol consumption

机译：BDNF Val66Met和与奖赏相关的青少年脑功能：早期饮酒的作用

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Changes in reward processing have been identified as one important pathogenetic mechanism in alcohol addiction. The nonsynonymous single nucleotide polymorphism in the brain-derived neurotrophic factor (BDNF) gene (rs6265/Val66Met) modulates the central nervous system activity of neurotransmitters involved in reward processing such as serotonin, dopamine, and glutamate. It was identified as crucial for alcohol consumption in healthy adults and, in rats, specifically related to the function in the striatum, a region that is commonly involved in reward processing. However, studies in humans on the association of BDNF Val66Met and reward-related brain functions and its role for alcohol consumption, a significant predictor of later alcohol addiction, are missing. Based on an intermediate phenotype approach, we assessed the early orientation toward alcohol and alcohol consumption in 530 healthy adolescents that underwent a monetary incentive delay task,during functional magnetic resonance imaging. We found a significantly lower response in the putamen to reward anticipation in adolescent Met carriers with high versus low levels of alcohol consumption. During reward feedback, Met carriers with low putamen reactivity were significantly more likely to orient toward alcohol and to drink alcohol 2 years later. This study indicates a possible effect of BDNF Val66Met on alcohol addiction-related phenotypes in adolescence. (C) 2015 Elsevier Inc. All rights reserved.
机译：奖励过程的变化已被确定为酒精成瘾的重要发病机制之一。脑源性神经营养因子（BDNF）基因（rs6265 / Val66Met）中的非同义单核苷酸多态性可调节参与奖赏加工的神经递质的中枢神经系统活性，这些递质包括5-羟色胺，多巴胺和谷氨酸。它被认为对健康成年人和大鼠的饮酒至关重要，特别是与纹状体中的功能有关，该区域通常参与奖励过程。但是，关于BDNF Val66Met与奖赏相关的脑功能及其在饮酒中的作用（后者是以后饮酒成瘾的重要预测因素）之间的关系的人类研究尚缺乏。基于中间表型方法，我们评估了功能性磁共振成像期间接受金钱诱因延迟任务的530名健康青少年的酒精和酒精消费的早期倾向。我们发现，酒精摄入量高或低的青春期Met携带者对预期的预期反应中，壳聚糖的反应显着降低。在奖励反馈过程中，壳聚糖反应性较低的Met携带者在两年后更有可能倾向于饮酒和饮酒。这项研究表明BDNF Val66Met对青少年酒精成瘾相关表型的可能影响。 （C）2015 Elsevier Inc.保留所有权利。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号