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首页> 外文期刊>Alcohol >Evolution of the DRD2 gene haplotype and its association with alcoholism in Mexican Americans.
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Evolution of the DRD2 gene haplotype and its association with alcoholism in Mexican Americans.

机译：墨西哥裔美国人DRD2基因单倍型的进化及其与酒精中毒的关系。

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The human D2 dopamine receptor gene (DRD2) plays a central role in the neuromodulation of appetitive behaviors and is implicated in having a possible role in susceptibility to alcoholism. We genotyped an SNP in DRD2 Exon 8 in 251 nonalcoholic, unrelated, healthy controls and 200 alcoholic Mexican Americans. The DRD2 haplotypes were analyzed using the Exon 8 genotype in combination with five other SNP genotypes, which were obtained from our previous study. The ancestral origins of the DRD2 polymorphisms have been determined by sequencing the homologous region in other higher primates. Twenty DRD2 haplotypes, defined as H1 to H20 based on their frequency from high to low, were obtained in this major minority population. The ancestral haplotype "I-B2-G-C-G-A1" and two one-step mutation haplotypes were absent in our study population. The haplotype H1, I-B1-T-C-A-A1 three-step mutation from the ancestral form. The first five or eight major haplotypes make up 87% or 95% of the entire population, respectively. The prevalence of the haplotype H1+ (H1/H1 and H1/Hn genotypes) is significantly higher in alcoholics and alcoholic subgroups, including early onset drinkers and benders, than in their respective control groups. The Promoter -141C allele is in linkage disequilibrium (LD) with five other loci in the nonalcoholic group, but not in the alcoholic group. All of the other five loci are in LD in both the alcoholic and control groups. The DRD2 TaqI B allele is in complete LD with the allele located in intron 6. Five SNPs, Promoter -141C, TaqI B (or Intron 6), Exon 7, Exon 8, and TaqI A, are sufficient to define the DRD2 haplotypes in Mexican Americans. Our data indicate that the DRD2 haplotypes are associated with alcoholism in Mexican Americans.
机译：人类D2多巴胺受体基因（DRD2）在食欲行为的神经调节中起着核心作用，并暗示可能对酒精中毒易感。我们对251名非酒精，无关，健康对照和200名墨西哥裔墨西哥人的DRD2外显子8中的SNP进行了基因分型。使用我们的先前研究获得的外显子8基因型与其他五种SNP基因型相结合来分析DRD2单倍型。 DRD2多态性的祖先起源已通过对其他高级灵长类动物中的同源区域进行测序来确定。在这个主要的少数族裔中，获得了20种DRD2单倍型，根据其频率从高到低的顺序定义为H1至H20。在我们的研究人群中没有祖先的单倍型“ I-B2-G-C-G-A1”和两个单步突变单倍型。单倍型H1，I-B1-T-C-A-A1从祖先形式开始的三步突变。前五种或八种主要单倍型分别占总人口的87％或95％。在酗酒者和酗酒者亚组中，包括早期发作的饮酒者和弯腰者，单倍型H1 +（H1 / H1和H1 / Hn基因型）的患病率明显高于对照组。启动子-141C等位基因与非酒精性组中的五个其他基因座处于连锁不平衡（LD），但酒精性组中不存在。其他五个基因座在酒精和对照组中均处于LD。 DRD2 TaqI B等位基因与位于内含子6的等位基因处于完全LD。五个SNP，启动子-141C，TaqI B（或内含子6），外显子7，外显子8和TaqI A足以定义DRD2单倍型。墨西哥裔美国人。我们的数据表明DRD2单倍型与墨西哥裔美国人的酗酒有关。

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