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首页> 外文期刊>Alcohol >Acute ethanol counteracts the acquisition of aversive olfactory learning in infant rats.
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Acute ethanol counteracts the acquisition of aversive olfactory learning in infant rats.

机译：急性乙醇会抵消婴儿大鼠厌恶性嗅觉学习的获得。

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Rodents are particularly prone to acquire associative memories during early stages of life. Yet, very little is known about how ethanol interacts with simultaneous associative learning acquired during postabsorptive periods. We have recently observed that preweanling rats avoid lemon odor previously paired with the intraoral infusion of a sapid sweet solution, a result likely to be caused by aversive consequences inherent to this procedure. Two experiments were conducted to analyze the effects of acute ethanol upon the acquisition of this avoidance response. Fourteen-day-old Wistar rats were intragastrically administered with ethanol (0.0, 0.25, 0.5, or 1.25 g/kg) and then exposed for 5 min to a lemon-scented chamber while being intraorally infused with sucrose (12% vol/vol). Four of such pairings were conducted immediately after ethanol administration. Control pups experienced these stimuli in an unrelated fashion. On postnatal day 15 animals were tested in a 5-min, two-way odor-preference test. Pups administered with vehicle during the acquisition phase exhibited a strong aversion to the lemon odor relative to control subjects. This avoidance response was reduced in pups that received 0.5 and 1.25 g/kg doses, whereas it completely vanished in those that received 0.25 g/kg dose. In a second experiment it was observed that, 10 min after the administration, blood ethanol concentrations attained with the 0.25, 0.5, and 1.25 g/kg doses were 11, 39, and 83 mg%, respectively. These data indicate that a very low dose of ethanol is able to counteract early aversive associative learning, a result likely to be mediated by anxiolytic properties of ethanol.
机译：啮齿动物在生命的早期特别容易获得联想记忆。然而，关于乙醇如何与吸收后时期获得的同时联想学习相互作用的信息知之甚少。我们最近观察到，断奶前的老鼠避免了柠檬味，而此前柠檬味与口服甜味甜味剂配对使用可能是由该过程固有的厌恶后果引起的。进行了两个实验来分析急性乙醇对获得这种避免反应的影响。向14天大的Wistar大鼠胃内施用乙醇（0.0、0.25、0.5或1.25 g / kg），然后在口服含蔗糖（12％vol / vol）的情况下暴露于柠檬味室5分钟。乙醇施用后立即进行了四个这样的配对。对照幼崽以不相关的方式经历了这些刺激。出生后第15天，对动物进行了5分钟的双向气味偏好测试，测试时间为5分钟。相对于对照对象，在采集阶段与媒介物一起给药的幼仔表现出强烈的柠檬味厌恶感。在分别接受0.5和1.25 g / kg剂量的幼犬中，这种回避反应的反应减弱了，而在接受0.25 g / kg剂量的幼犬中，其完全消失了。在第二个实验中，观察到在给药后10分钟，以0.25、0.5和1.25g / kg的剂量达到的血液乙醇浓度分别为11、39和83mg％。这些数据表明，非常低剂量的乙醇能够抵消早期的厌恶联想学习，这可能是由乙醇的抗焦虑特性介导的。

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