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首页> 外文期刊>Zeitschrift fur Anorganische und Allgemeine Chemie >A Water‐Soluble Mn(CO) 33 ‐Based and Non‐Toxic PhotoCORM for Administration of Carbon Monoxide Inside of Cells
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A Water‐Soluble Mn(CO) 33 ‐Based and Non‐Toxic PhotoCORM for Administration of Carbon Monoxide Inside of Cells

机译:用于施用电池内的一氧化碳的水溶性Mn(CO)<亚次> 3次和无毒的光学感染型

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摘要

> The photoCORMs [Mn(CO) 3 (L)]Br with the tridentate ligands L1 = S[(CH 2 ) 2 NH 2 ] 2 ( 1 ) (CORM‐EDE3) and L2 = cyclo ‐S[(CH 2 ) 2 NH(CH 2 ‐)] 2 ( 2 ) (CORM‐EDE4) are non‐toxic and release all CO ligands upon irradiation. Reduction of the hydrophilicity of the cation by L2 (thia‐4,7‐diazacyclononane) enables accumulation of the resulting water‐soluble CORM‐EDE4 as well as administration of CO inside of cells.
机译: >具有三齿配体L1 = S的光电振动[Mn(Co) 3 (l)] br [(ch 2 2 nh 2 ] 2 ( 1 )(corm-ede3)和l2 = cyclo -s [(ch 2 2 nh(ch 2 - )] 2 ( 2 )(CORM-EDE4)无毒,并在照射时释放所有CO配体。 通过L2(Thia-4,7-二扎族甘氨酸)降低阳离子的亲水性,使得所得水溶性肠胚层的积累以及施用CO在细胞内部。

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  • 作者单位

    Institute of Inorganic and Analytical ChemistryFriedrich Schiller UniversityHumboldtstra?e 8 07743 Jena Germany;

    Center for Sepsis Control and Care (CSCC)Jena University HospitalAm Klinikum 1 07747 Jena Germany;

    Leibniz Institute of Photonic Technology (Leibniz IPHT)Albert‐Einstein‐Stra?e 9 07745 Jena Germany;

    Institute of Inorganic and Analytical ChemistryFriedrich Schiller UniversityHumboldtstra?e 8 07743 Jena Germany;

    Leibniz Institute of Photonic Technology (Leibniz IPHT)Albert‐Einstein‐Stra?e 9 07745 Jena Germany;

    Center for Sepsis Control and Care (CSCC)Jena University HospitalAm Klinikum 1 07747 Jena Germany;

    Center for Molecular Biomedicine (CMB)Friedrich Schiller University Jena and Jena University HospitalHans‐Kn?ll‐Stra?e 2 07745 Jena Germany;

    Center for Molecular Biomedicine (CMB)Friedrich Schiller University Jena and Jena University HospitalHans‐Kn?ll‐Stra?e 2 07745 Jena Germany;

    Center for Sepsis Control and Care (CSCC)Jena University HospitalAm Klinikum 1 07747 Jena Germany;

    Institute of Inorganic and Analytical ChemistryFriedrich Schiller UniversityHumboldtstra?e 8 07743 Jena Germany;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;
  • 关键词

    CORMs; photoCORMs; Manganese; Manganese carbonyl; Crystal structure;

    机译:蜗虫;光电振动;锰;锰羰基;晶体结构;

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