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首页> 外文期刊>Zeitschrift fur Arznei- und Gewurzpflanzen >Previous Helicobacter pylori infection-induced atrophic gastritis: A distinct disease entity in an understudied population without a history of eradication
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Previous Helicobacter pylori infection-induced atrophic gastritis: A distinct disease entity in an understudied population without a history of eradication

机译：以前的幽门螺杆菌感染诱导的萎缩性胃炎：在没有根除历史的情况下，在一个人的人口中有明显的疾病实体

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Individuals with chronic atrophic gastritis who are negative for active H. pylori infection with no history of eradication therapy have been identified in clinical practice. By excluding false-negative and autoimmune gastritis cases, it can be surmised that most of these patients have experienced unintentional eradication of H. pylori after antibiotic treatment for other infectious disease, unreported successful eradication, or H. pylori that spontaneously disappeared. These patients are considered to have previous H. pylori infection-induced atrophic gastritis. In this work, we define these cases based on the following criteria: absence of previous H. pylori eradication; atrophic changes on endoscopy or histologic confirmation of glandular atrophy; negative for a current H. pylori infection diagnosed in the absence of proton-pump inhibitors or antibiotics; and absence of localized corpus atrophy, positivity for autoantibodies, or characteristic histologic findings suggestive of autoimmune gastritis. The risk of developing gastric cancer depends on the atrophic grade. The reported rate of developing gastric cancer is 0.31%-0.62% per year for successfully eradicated severely atrophic cases (pathophysiologically equal to unintentionally eradicated cases and unreported eradicated cases), and 0.53%-0.87% per year for spontaneously resolved cases due to severe atrophy. Therefore, for previous H. pylori infection-induced atrophic gastritis cases, we recommend endoscopic surveillance every 3 years for high-risk patients, including those with endoscopically severe atrophy or intestinal metaplasia. Because of the difficulty involved in the endoscopic diagnosis of gastric cancer in cases of previous infection, appropriate monitoring of the high-risk subgroup of this understudied population is especially important.
机译：患有慢性萎缩性胃炎的个体对于活性H.幽门螺杆菌感染没有根除治疗史的幽门螺杆菌感染。通过排除假阴性和自身免疫性胃膜炎的病例，可以抑制大多数这些患者在抗生素治疗后经历了无意的H. Pylori，用于其他传染病，未报告的成功删除或自发消失的幽门螺杆菌。这些患者被认为具有以前的H.幽门螺杆菌感染诱导的萎缩性胃炎。在这项工作中，我们根据以下标准定义这些案例：缺乏先前的H.幽门螺杆菌根除;内窥镜检查或腺体萎缩的组织学确认的萎缩变化;在没有质子泵抑制剂或抗生素的情况下被诊断出的当前H.幽门感染的阴性;并且没有局部语料库萎缩，自身抗体的阳性，或暗示自身免疫性胃炎的特征组织学结果。发育胃癌的风险取决于萎缩级。报告的胃癌患者每年成功消除萎缩病例（病理物理学上等于无意地消除的病例和未报告的消除病例），每年0.53％-0.87％，由于严重的萎缩，每年0.53％-0.87％。 。因此，对于先前的幽门螺杆菌感染诱导的萎缩性胃膜炎病例，我们建议在高危患者中每3年的每3年内窥镜监测，包括具有内窥镜严重的萎缩或肠道细胞的人。由于难以参与胃癌的内镜诊断，以前感染的情况下，适当监测这种被描述的人口的高危亚组是尤为重要的。

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