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首页> 外文期刊>Zeitschrift fur Arznei- und Gewurzpflanzen >Bioplatform Fabrication Approaches Affecting Chitosan-Based Interpolymer Complex Properties and Performance as Wound Dressings
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Bioplatform Fabrication Approaches Affecting Chitosan-Based Interpolymer Complex Properties and Performance as Wound Dressings

机译：生物塑料制造方法，影响基于壳聚糖的互聚合物复合物质和性能作为伤口敷料

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摘要

Chitosan can form interpolymer complexes (IPCs) with anionic polymers to form biomedical platforms (BMPs) for wound dressing/healing applications. This has resulted in its application in various BMPs such as gauze, nano/microparticles, hydrogels, scaffolds, and films. Notably, wound healing has been highlighted as a noteworthy application due to the remarkable physical, chemical, and mechanical properties enabled though the interaction of these polyelectrolytes. The interaction of chitosan and anionic polymers can improve the properties and performance of BMPs. To this end, the approaches employed in fabricating wound dressings was evaluated for their effect on the property-performance factors contributing to BMP suitability in wound dressing. The use of chitosan in wound dressing applications has had much attention due to its compatible biological properties. Recent advancement includes the control of the degree of crosslinking and incorporation of bioactives in an attempt to enhance the physicochemical and physicomechanical properties of wound dressing BMPs. A critical issue with polyelectrolyte-based BMPs is that their effective translation to wound dressing platforms has yet to be realised due to the unmet challenges faced when mimicking the complex and dynamic wound environment. Novel BMPs stemming from the IPCs of chitosan are discussed in this review to offer new insight into the tailoring of physical, chemical, and mechanical properties via fabrication approaches to develop effective wound dressing candidates. These BMPs may pave the way to new therapeutic developments for improved patient outcomes.
机译：壳聚糖可以形成具有阴离子聚合物的互聚合物（IPC），形成伤口敷料/愈合应用的生物医学平台（BMP）。这导致其在各种BMP中的应用，例如纱布，纳米/微粒，水凝胶，支架和薄膜。值得注意的是，由于这些聚电解质的相互作用，因此突出了伤口愈合作为一种值得注意的应用，因为这些聚合物的相互作用使得能够实现。壳聚糖和阴离子聚合物的相互作用可以改善BMP的性能和性能。为此，评价制造伤口敷料的方法对其对伤口敷料中BMP适用性有助于BMP适用性的影响。由于其相容的生物学性质，壳聚糖在伤口敷料应用中的使用具有很大的关注。最近的进步包括控制交联程度和生物透明度，以提高伤口敷料BMP的物理化学和物理机械性质。基于聚电解质的BMP的关键问题是，由于在模仿复杂和动态伤口环境时面临的未满足挑战，他们对伤口敷料平台的有效翻译尚未实现。在本综述中讨论了从壳聚糖IPC的新型BMPS，以通过制造方法剪裁物理，化学品和机械性能来开发有效的伤口敷料候选者来讨论新的BMP。这些BMP可以为新的治疗发展铺平道路，以改善患者结果。

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