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首页> 外文期刊>Alcohol >Intake of ethanol and reinforcing fluids in rats bred for susceptibility to stress.
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Intake of ethanol and reinforcing fluids in rats bred for susceptibility to stress.

机译：在大鼠中摄入乙醇和补液对压力很敏感。

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Rats have been selectively bred in our laboratory based on how swim-test behavior is affected by stress. Following exposure to an acute stressor, active swim-test behavior is reduced in the swim-test susceptible (SUS) line but is not reduced in the swim-test resistant (RES) line. Earlier findings indicate that SUS rats have reduced central serotonin and dopamine levels relative to normal, random-bred (i.e., nonselected [NS]) rats and RES rats, suggesting that SUS rats might respond differently to reinforcing substances, particularly ethanol. We report here comparison of SUS, NS, and RES rats regarding consumption of ethanol. Also examined was consumption of saccharin, sucrose, and quinine. Testing involved a two-bottle, free-choice method of measuring intake of substances in a home cage. Intake of each substance was tested across a range of concentrations. The results indicate that the SUS rats, tested across 14 generations, consume markedly more ethanol than the other two lines; in fact, SUS rats consume amounts similar to that ingested by lines/strains of rats bred specifically for ethanol intake. Similar to other alcohol-preferring rats, SUS rats show an increased affinity for saccharin solutions and a marked increase in their total daily fluid intake when a sweet-tasting saccharin or sucrose solution is available. These results indicate that a propensity to drink alcohol occurs in a line of rats that were selectively bred, not for alcohol intake, but for vulnerability to stress.
机译：根据压力对游泳测试行为的影响，在我们的实验室中选择性培养了大鼠。暴露于急性应激源后，活跃的游泳测试行为在易受游泳测试（SUS）品系中降低，但在抗游泳测试（RES）品系中未降低。较早的发现表明，相对于正常，随机繁殖（即非选择的[NS]）大鼠和RES大鼠，SUS大鼠的中枢血清素和多巴胺水平降低，这表明SUS大鼠对增强物质（尤其是乙醇）的反应可能不同。我们在这里报告SUS，NS和RES大鼠在乙醇消耗方面的比较。还检查了糖精，蔗糖和奎宁的消耗量。测试涉及两瓶自由选择的方法来测量家用笼中物质的摄入量。在各种浓度下测试每种物质的摄入量。结果表明，经过14代测试的SUS大鼠的乙醇消耗量明显多于其他两条系。实际上，SUS大鼠的摄入量与专门为摄入乙醇而饲养的大鼠品系/品系摄入的量相似。与其他偏爱酒精的大鼠类似，SUS大鼠显示出对糖精溶液的亲和力增加，并且当可获得甜味糖精或蔗糖溶液时，其每日总液体摄入量显着增加。这些结果表明，在一群选择性饲养的大鼠中发生饮酒的倾向，不是为了饮酒，而是为了抵抗压力。

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