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首页> 外文期刊>Zoonoses and Public Health >Transmission and immunopathology of the avian influenza virus A/Anhui/1/2013 (H7N9) human isolate in three commonly commercialized avian species
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Transmission and immunopathology of the avian influenza virus A/Anhui/1/2013 (H7N9) human isolate in three commonly commercialized avian species

机译：禽流感病毒的传播和免疫病理学A / Anhui / 1/2013（H7N9）人类孤立在三种常见商业化的禽类中

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摘要

H7N9 virus infection is a global concern, given that it can cause severe infection and mortality in humans. However, the understanding of H7N9 epidemiology, animal reservoir species and zoonotic risk remains limited. This work evaluates the pathogenicity, transmissibility and local innate immune response of three avian species harbouring different respiratory distribution of 2,6 and 2,3 SA receptors. Muscovy ducks, European quails and SPF chickens were intranasally inoculated with 10(5) embryo infectious dose (EID)(50) of the human H7N9 (A/Anhui/1/2013) influenza isolate. None of the avian species showed clinical signs or macroscopic lesions, and only mild microscopic lesions were observed in the upper respiratory tract of quail and chickens. Quail presented more severe histopathologic lesions and avian influenza virus (AIV) positivity by immunohistochemistry (IHC), which correlated with higher IL-6 responses. In contrast, Muscovy ducks were resistant to disease and presented higher IFN and TLR7 response. In all species, viral shedding was higher in the respiratory than in the digestive tract. Higher viral shedding was observed in quail, followed by chicken and ducks, which presented similar viral titres. Efficient transmission was observed in all contact quail and half of the Muscovy ducks, while no transmission was observed between chicken. All avian species showed viral shedding in drinking water throughout infection.
机译：H7N9病毒感染是全球担忧，因为它会导致人类的严重感染和死亡率。然而，了解H7N9流行病学，动物储层物种和人畜共济果风险仍然有限。这项工作评估了含有2,6和2,3个受体的不同呼吸分布的三禽类的致病性，传播和局部先天免疫应答。墨西哥鸭，欧洲鹌鹑和SPF鸡鼻内接种了10（5）个胚胎感染剂量（Eid）（50）的人H7N9（A / Anhui / 1/2013）流感分离物。禽类均没有显示出临床症状或宏观病变，并且在鹌鹑和鸡的上呼吸道中观察到轻微的显微病变。鹌鹑通过免疫组织化学（IHC）呈现了更严重的组织病理病变和禽流感病毒（AIV）阳性，其与较高的IL-6反应相关。相比之下，番鸭对疾病抗性，并呈现出更高的IFN和TLR7反应。在所有物种中，呼吸中的病毒脱落均高于消化道。在鹌鹑中观察到较高的病毒脱落，其次是鸡肉和鸭子，呈现出类似的病毒滴度。在所有接触鹌鹑和一半的斯科鸭中观察到高效传输，而鸡肉之间没有观察到速度。所有禽类都显示出在整个感染的饮用水中的病毒脱落。

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  • 来源
    《Zoonoses and Public Health》 |2018年第3期|共10页
  • 作者

    Vidana B.; Dolz R.; Busquets N.; Ramis A.; Sanchez R.; Rivas R.; Valle R.; Cordon I.; Solanes D.; Martinez J.; Majo N.;

  • 作者单位

    APHA Pathol Dept Pathol Addlestone KT15 3NB Surrey England;

    UAB IRTA Ctr Recerca Sanitat Anim CReSA Campus Univ Autonoma Barcelona Bellaterra Spain;

    UAB IRTA Ctr Recerca Sanitat Anim CReSA Campus Univ Autonoma Barcelona Bellaterra Spain;

    UAB IRTA Ctr Recerca Sanitat Anim CReSA Campus Univ Autonoma Barcelona Bellaterra Spain;

    UAB IRTA Ctr Recerca Sanitat Anim CReSA Campus Univ Autonoma Barcelona Bellaterra Spain;

    UAB IRTA Ctr Recerca Sanitat Anim CReSA Campus Univ Autonoma Barcelona Bellaterra Spain;

    UAB IRTA Ctr Recerca Sanitat Anim CReSA Campus Univ Autonoma Barcelona Bellaterra Spain;

    UAB IRTA Ctr Recerca Sanitat Anim CReSA Campus Univ Autonoma Barcelona Bellaterra Spain;

    UAB IRTA Ctr Recerca Sanitat Anim CReSA Campus Univ Autonoma Barcelona Bellaterra Spain;

    UAB IRTA Ctr Recerca Sanitat Anim CReSA Campus Univ Autonoma Barcelona Bellaterra Spain;

    UAB IRTA Ctr Recerca Sanitat Anim CReSA Campus Univ Autonoma Barcelona Bellaterra Spain;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 动物医学（兽医学）;
  • 关键词

    avian influenza; chicken; duck; H7N9; quail; water;

    机译：禽流感;鸡;鸭;H7N9;鹌鹑;水;

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