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首页> 外文期刊>Zoonoses and Public Health >Hepatitis E virus in Common voles (Microtus arvalis) from an urban environment, Hungary: Discovery of a Cricetidae-specific genotype of Orthohepevirus C
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Hepatitis E virus in Common voles (Microtus arvalis) from an urban environment, Hungary: Discovery of a Cricetidae-specific genotype of Orthohepevirus C

机译：来自城市环境的普遍葡萄球菌（Microotus Arvalis）的乙型肝炎病毒，匈牙利：发现患有癌症的癌症特异性基因型C.

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摘要

Hepatitis E virus is a major causative agent of acute hepatitis worldwide. Despite its zoonotic potential, there is limited information about the natural chain of hepevirus infection in wildlife, and the potential reservoir species. In this study, we performed a HEV survey by heminested RT-PCR on rodent samples from an urban environment (in the city of Pecs, Hungary) and investigated the prevalence of the virus among these native rodent species (Apodemus agrarius, Apodemus flavicollis, Apodemus sylvaticus, Microtus arvalis and Myodes glareolus). HEV was detected exclusively in Common voles (M. arvalis), in 10.2% of screened voles, and 3.2% of all investigated samples from all species. Based on the phylogenetic analysis, our strain showed the closest homology with European Orthohepevirus C strains detected previously in faecal samples of birds of prey and Red fox, supporting the possibility of the dietary origin of these strains. In addition, our samples showed close phylogenetic relation with a South American strain detected in Necromys lasiurus (Cricetidae), but separated clearly from other Muridae-associated strains, suggesting the presence of a Cricetidae-specific genotype in Europe and South-America. Based on these results, we hypothesize the reservoir role of M. arvalis rodents for the European Cricetidae-specific Orthohepevirus C genotype.
机译：乙型肝炎病毒是全球急性肝炎的主要致病因子。尽管其具有人群潜力，但有关野生动物的肺病毒感染的自然链的信息有限，潜在的水库物种。在这项研究中，我们对来自城市环境（在PEC市，匈牙利市）的啮齿动物样本上进行了HEV调查，并调查了这些本地啮齿动物物种中病毒的患病率（Apodemus Agrarius，Apodemus flavicollis，Apodemus Sylvaticus，microotus arvalis和myodes glareolus）。 HEV仅在常见的葡萄球菌（M.Arvalis）中，在10.2％的筛选损失中检测，所有物种的所有研究样品的3.2％。在系统发育分析的基础上，我们的菌株显示出先前在捕食性和红狐狸鸟类样品中检测到的欧洲牙龈血清菌株最近的同源性，支持这些菌株的膳食起源的可能性。此外，我们的样品表明，在Necromys Lasiurus（克里克尼达岛）中检测到南美菌株的南美菌，但清楚地与其他相关菌株分开，表明欧洲和南美的特异性基因型的存在。基于这些结果，我们假设M.Arvalis啮齿动物对欧洲克里克尼啶特异性肠蠕病症C基因型的储层作用。

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