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首页> 外文期刊>Zeitschrift fur Naturforschung, B. A Journal of Chemical Sciences >Bioactive chemical constituents from the resin of Aloe vera
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Bioactive chemical constituents from the resin of Aloe vera

机译:来自芦荟树脂的生物活性化学成分

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摘要

Bioassay-guided fractionation of Aloe vera (L.) Burm.f. resulted in the isolation and characterization of one new C-glucosyl chromone, 7-methoxy-6′-O-coumaroylaloesin (1), along with the known dihydroisocoumarin feralolide (2). The structure of 1 was elucidated on the basis of 1D, 2D-NMR, and mass spectrometry. Both compounds 1 and 2 were tested for their effects on the growth of cancer cells in culture and it was observed that unlike compound 1, compound 2 displayed concentration-dependent antiproliferative effects on breast cancer cells (MDA-MB-231) and ovarian cancer cells (SKOV-3). Additionally, only feralolide (2) demonstrated good urease, weak α-glucosidase enzyme inhibition, and weak antioxidant effects.
机译:芦荟(L.)Burm.f的生物测定引导分馏。 导致一个新的C-葡萄糖酰铬酮,7-甲氧基-6'-O-香豆酵母LaloOSIN(1)的分离和表征,以及已知的二氢脲oumarin硅素(2)。 基于1D,2D-NMR和质谱法阐明了1的结构。 测试了化合物1和2的对培养中癌细胞生长的影响,观察到与化合物1不同,化合物2显示对乳腺癌细胞(MDA-MB-231)和卵巢癌细胞的浓度依赖性抗增殖作用 (SKOV-3)。 此外,只有硅丙烯酸酯(2)才显示出良好的脲酶,弱α-葡糖苷酶抑制,弱抗氧化效果。

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    UoN Chair of Oman’s Medicinal Plants and Marine Natural Products University of Nizwa P.O. Box 33 Postal Code 616 Birkat Al Mauz Nizwa Sultanate of Oman;

    UoN Chair of Oman’s Medicinal Plants and Marine Natural Products University of Nizwa P.O. Box 33 Postal Code 616 Birkat Al Mauz Nizwa Sultanate of Oman Tel.: +968-2544-6328 Fax: +968-2544-6612;

    UoN Chair of Oman’s Medicinal Plants and Marine Natural Products University of Nizwa P.O. Box 33 Postal Code 616 Birkat Al Mauz Nizwa Sultanate of Oman;

    UoN Chair of Oman’s Medicinal Plants and Marine Natural Products University of Nizwa P.O. Box 33 Postal Code 616 Birkat Al Mauz Nizwa Sultanate of Oman;

    Department of Biological Sciences and Chemistry University of Nizwa P.O. Box 33 Postal Code 616 Birkat Al Mauz Nizwa Sultanate of Oman;

    Department of Chemistry and Polymer Science University of Stellenbosch P/Bag X1 Matieland 7602 South Africa;

    UoN Chair of Oman’s Medicinal Plants and Marine Natural Products University of Nizwa P.O. Box 33 Postal Code 616 Birkat Al Mauz Nizwa Sultanate of Oman Tel.: +968-2544-6328 Fax: +968-2544-6612;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;
  • 关键词

    Aloe vera; biological effects; coumarin; natural products; structure elucidation;

    机译:芦荟;生物效应;香豆素;天然产品;结构阐明;

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