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首页> 外文期刊>Vox Sanguinis: International Journal of Blood Transfusion and Immunohaematology >Anti-Rh D activity of commercial intravenous immunoglobulin preparations.
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Anti-Rh D activity of commercial intravenous immunoglobulin preparations.

机译：商业静脉内免疫球蛋白制剂的抗RH D活性。

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摘要

BACKGROUND AND OBJECTIVES: The presence of antibodies against Rh D in intravenous immunoglobulin (IVIG) products has been proposed as causing adverse reactions and blood grouping problems, although data on the incidence and titre of such antibodies is sketchy. This study was conducted to investigate methodology for carrying out haemagglutination tests on IVIG products, and to examine in retrospect 200 IVIG batches for the presence of anti-D and other haemagglutinins. MATERIALS AND METHODS: Batches of commercial IVIG products were tested using the low-ionic-strength indirect antiglobulin test (LIAT). Positive batches were further investigated using a typed red cell panel and direct haemagglutination tests. RESULTS: 44 batches of IVIG gave positive LIAT. Of these, 12 contained specific anti-D. 11 batches had LIAT anti-D titres of 2-8; a further batch contained anti-D with a LIAT titre of 64. The remaining 32 batches agglutinated all erythrocyte phenotypes tested with LIAT titres
机译：背景和目标：已经提出了对静脉内免疫球蛋白（IVIG）产品的抗体的存在，导致不良反应和血液分组问题，尽管对这种抗体的发生率和滴度是粗略的数据。进行该研究以调查用于对IVIG产品进行血凝试验的方法，并回顾抗D和其他血凝素存在的200 IVIG批次。材料和方法：使用低离子强度间接抗气蛋白检测（肝脏）测试批次的商业IVIG产物。进一步研究使用类型化的红细胞面板和直接血凝试验进一步研究正批次。结果：44分批次的IVIG给了阳性李海。其中，12个含有特定的抗D. 11批含有2-8的抗D滴度;进一步的批次包含抗D率为64.剩下的32批粘结用肝滴度测试的所有红细胞表型

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