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首页> 外文期刊>Vox Sanguinis: International Journal of Blood Transfusion and Immunohaematology >Does prophylactic calcium in apheresis cause more harm than good? – Centre heterogeneity within the World Apheresis Association Register prevents firm conclusions Centre heterogeneity within the World Apheresis Association Register prevents firm conclusions
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Does prophylactic calcium in apheresis cause more harm than good? – Centre heterogeneity within the World Apheresis Association Register prevents firm conclusions Centre heterogeneity within the World Apheresis Association Register prevents firm conclusions

机译：预防性钙是否在容易填充物中会导致更好的伤害？ - 世界阿草属关联注册内的中心异质性防止了世界阿草部分协会登记术中的坚定结论中心异质性阻止了坚定的结论

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Background and objectives Symptomatic hypocalcaemia is common during apheresis procedures based on citrate‐based anticoagulants. As a consequence, patients often receive prophylactic calcium treatment. However, a recent publication based on the World Apheresis Association ( WAA ) register suggested harmful effects of such prophylactic calcium use. Recognizing possible limitations in the previous WAA register analyses, we critically re‐evaluate the data, to test whether a change in prophylactic calcium usage may be warranted. Materials and methods Using the WAA register, we reanalysed previous data by means of centre and treatment type stratification, to explore the role of prophylactic calcium as a risk factor for adverse events. Results There was large variability in adverse event rates dependent on the centre performing the apheresis procedure and dependent on the type of procedure. When this variability was accounted for, there was no clear effect of calcium administration on risk of adverse effects. Conclusion Shortcomings in the previous WAA register analyses may have failed to account for important confounding factors resulting in a substantial overestimation of the risk attributable to calcium usage. Overall our findings do not support a negative effect of prophylactic calcium administration in the apheresis setting.
机译：背景和目标在基于柠檬酸盐的抗凝血剂的植物内程序期间症状性低钙血症是常见的。结果，患者通常会获得预防性钙治疗。然而，最近基于世界筛查协会（WAA）寄存器的出版表明这种预防性钙使用的有害影响。识别在以前的WAA寄存器分析中可能的限制，我们重新评估数据，以测试是否有保证预防性钙使用的变化。使用WAA寄存器的材料和方法，我们通过中心和治疗类型分层重新安排了先前的数据，探讨了预防性钙作为不良事件的危险因素的作用。结果依赖于执行洗手序手术的中心并取决于程序类型的不良事件率存在较大的变化。当这种变异算是时，钙管理钙对不利影响风险没有明显的影响。结论前一届WAA寄存器分析中的缺点可能未能考虑重要的混淆因素，导致对钙使用的风险显着高估。总体而言，我们的发现不支持预防性钙施用在洗脱液环境中的负面影响。

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