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Evaluation of oxygen mass transfer in Aspergillus niger fermentation using data reconciliation

机译:使用数据协调评估黑曲霉发酵过程中的氧气传质

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Fermentation experiments using Aspergillus niger result in a very viscous broth due to the growth of filamentous microorganism. For viscous fermentation processes, it is difficult to estimate with confidence the volumetric oxygen mass transfer coefficient (K(L)alpha), which can be used for scale-up or design of bioreactors. In the present study, four methods based on dynamic and stationary approaches were used to measure K(L)alpha throughout the fermentation. Data reconciliation was used to obtain a more reliable and consistent K(L)alpha. The K(L)alpha value obtained by a data reconciliation technique was found to be more reliable since it takes into consideration both the reliability of all measured variables and the accuracy of all mass balance equations.
机译:由于丝状微生物的生长,使用黑曲霉的发酵实验产生了非常粘的肉汤。对于粘性发酵过程,很难可靠地估算出可用于放大或设计生物反应器的体积氧传质系数(K(L)alpha)。在本研究中,基于动态和固定方法的四种方法被用来测量整个发酵过程中的K(L)alpha。数据协调用于获得更可靠和一致的K(L)alpha。发现通过数据调节技术获得的K(L)alpha值更可靠,因为它同时考虑了所有测量变量的可靠性和所有质量平衡方程式的准确性。

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