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Population balance approach to modeling hairy root growth

机译:人口平衡方法模拟毛状根的生长

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Though numerous models have been developed to describe the growth of microbial cell cultures, far fewer models are available to describe the growth of hairy root cultures. Here a population balance model is proposed to simulate the growth of hairy roots. The model accounts for the increase in biomass due to elongation of a branch by cell division as well as the formation of new branches. The model incorporates the fact that although the likelihood of the formation of a new lateral branch is a maximum at a specific age of the parent branch, lateral branches can form over a distribution of ages of the parent branch. Model parameters are estimated using the genetic algorithm based on experimental data for batch and continuous bioreactors. The model proposed here may provide a better understanding of the increase in biomass of hairy root cultures.
机译:尽管已经开发了许多模型来描述微生物细胞培养物的生长,但是描述毛状根培养物生长的模型却很少。这里提出了一种人口平衡模型来模拟毛状根的生长。该模型说明了由于细胞分裂引起的分支伸长以及新分支的形成,生物量的增加。该模型包含以下事实:尽管在母体分支的特定年龄处形成新的侧枝的可能性最大,但在母体分支的年龄分布中可以形成侧枝。使用遗传算法,基于分批和连续生物反应器的实验数据,估计模型参数。这里提出的模型可以更好地理解毛状根培养物生物量的增加。

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