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首页> 外文期刊>Depression research and treatment >Anxiolytic and Antidepressant Effects of Maerua angolensis DC. Stem Bark Extract in Mice
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Anxiolytic and Antidepressant Effects of Maerua angolensis DC. Stem Bark Extract in Mice

机译：Maerua Angolensis DC的抗焦虑和抗抑郁作用。 茎树皮提取物

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Introduction. The stem bark extract of Maerua angolensis DC. (Capparaceae) is used as a traditional remedy for management of anxiety, psychosis, and epilepsy. Aim of the Study. We therefore aimed at evaluating the anxiolytic and antidepressant potential of the plant in mice models. Methods. The dried stem bark was extracted with petroleum ether/ethyl acetate (50:50) mixture to obtain the extract, MAE. We employed Irwin’s test to identify the preliminary behavioral and autonomic effects. Subsequently, MAE was administered per os to male mice and subsequently assessed, 1 h later, for anxiety parameters in the elevated plus maze (EPM) and the regular Suok tests. The forced swim (FST) and tail suspension (TST) tests were employed to assess the antidepressant potential of the extract (100-1000 mg kg?1). Results. In our preliminary assay, MAE (100-5000 mg/kg) exhibited analgesic effects and a reduction in fear response in the Irwin’s test. The spontaneous locomotor activity was reduced at 1000 mg/kg. Additionally, MAE (1000 mg/kg) increased the latency to PTZ-induced convulsions, and duration to sleep in the pentobarbitone induced sleeping time assay. MAE (1000 mg/kg), similar to diazepam, in the anxiolytic assay, increased the percentage time spent in the open arms while decreasing protected head dips and unprotected stretch attend postures in the EPM. Correspondingly, there was a reduction in anxiety-induced immobility and freezing in the Suok test (300 mg/kg) without loss of sensorimotor coordination. Additionally, there was a significant reduction in immobility duration in the FST (300 mg/kg) and TST (1000 mg/kg). Conclusion. The petroleum ether/ethyl acetate fractions of Maerua angolensis stem bark possess anxiolytic and acute antidepressant effects in mice.
机译：介绍。 Maerua Angolensis DC的干树皮提取物。 （Capparaceae）被用作焦虑，精神病和癫痫管理的传统补救措施。该研究的目的。因此，我们旨在评估小鼠模型中植物的抗焦虑和抗抑郁药潜力。方法。用石油醚/乙酸乙酯（50:50）混合物萃取干燥的茎树皮，得到提取物，MAE。我们雇用了Irwin的测试来确定初步行为和自主主义效果。随后，每种OS给雄性小鼠给药，随后评估，1小时，以便在升高的Plus迷宫（EPM）和常规赛斗试验中进行焦虑参数。采用强制游泳（FST）和尾悬架（TST）测试来评估提取物的抗抑郁潜力（100-1000mgkg≤1）。结果。在我们的初步测定中，MAE（100-5000 mg / kg）表现出镇痛作用和IRWIN测试中恐惧反应的减少。自发运动活性以1000mg / kg降低。此外，MAE（1000 mg / kg）增加了PTZ诱导的抽搐等潜伏期，并且在戊巴比妥诱导的睡眠时间测定中睡眠持续时间。 Mae（1000 mg / kg）类似于Diazepam，在抗焦虑测定中，在张开臂上花费的百分比时间增加，同时降低了保护的头部垂度和未受保护的弹力参加EPM中的姿势。相应地，焦虑诱导的不动，在Suok试验（300mg / kg）中减少了焦虑诱导的不动，而不会损失感觉运动器协调。另外，FST（300mg / kg）和Tst（1000mg / kg）中的不动持续时间显着降低。结论。 Maerua Angolensis Steph Bark的石油醚/乙酸乙酯级分具有小鼠的抗焦虑和急性抗抑郁作用。

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