Modeling the quorum sensing regulatory network of human-pathogenic Pseudomonas aeruginosa

Viretta AU; Fussenegger M

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Modeling the quorum sensing regulatory network of human-pathogenic Pseudomonas aeruginosa

机译：建模人类致病性铜绿假单胞菌的群体感应调控网络

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The biochemical network underlying quorum sensing in human-pathogenic Pseudomonas aeruginosa is one of the best characterized. Mathematical modeling is required to untangle the complexity of its architecture and dynamics. We present a qualitative model of the P. aeruginosa quorum-sensing network including interactions between the las and rhl modules, the signaling molecule PQS and the regulatory proteins Mvfr and VfR. Simulations exemplify the model to reproduce natural network behavior and suggest quorum-sensing responses to pharmacological interference.

机译：人类致病性铜绿假单胞菌中群体感应的基础生化网络是特征最丰富的生物化学网络之一。需要进行数学建模才能解开其体系结构和动力学的复杂性。我们提出了铜绿假单胞菌群体感应网络的定性模型，包括las和rhl模块，信号分子PQS和调节蛋白Mvfr和VfR之间的相互作用。仿真例证了该模型以重现自然的网络行为，并提出了对药理干扰的群体感应反应。

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《Biotechnology Progress》 |2004年第3期|共9页
作者
Viretta AU; Fussenegger M;
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正文语种 eng
中图分类生物工程学（生物技术）;分子生物学;
关键词
To-cell communication; Segment polarity network; Luxr-luxi family; Mathematical-model; Gene-expression; Transcriptional control; Virulence; determinants; Secondary metabolites; Autoinducer analogs; Escherichia-coli;

机译：细胞间通讯;片段极性网络;Luxr-luxi家族;数学模型;基因表达;转录控制;毒力;行列式;次生代谢产物;自诱导物类似物;大肠杆菌;

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1. Modeling the quorum sensing regulatory network of human-pathogenic Pseudomonas aeruginosa [J] . Viretta AU, Fussenegger M Biotechnology Progress . 2004,第3期

机译：建模人类致病性铜绿假单胞菌的群体感应调控网络
2. Effects of Quorum Sensing Systems on Regulatory T Cells in Catheter-Related Pseudomonas aeruginosa Biofilm Infection Rat Models [J] . Feng Lei, Xiang Qingqing, Ai Qing, Mediators of inflammation . 2016,第Pta2期

机译：Quorum感测系统对导管相关假单胞菌铜绿假素感染大鼠模型的调节T细胞的影响
3. Uncovering the Dynamic Mechanisms of the Pseudomonas Aeruginosa Quorum Sensing and Virulence Networks Using Boolean Modelling [J] . Banzhaf Manuel, Resendis-Antonio Osbaldo, Zepeda-Mendoza M. Lisandra IEEE transactions on nanobioscience . 2020,第3期

机译：使用Boolean建模揭示假单胞菌铜绿假单胞菌Quorum感应和毒力网络的动态机制
4. Interaction of Quercetin with LasR of Pseudomonas aeruginosa: Mechanistic Insights of the Inhibition of Virulence Through Quorum Sensing [C] . H. V. Grabski, S. G. Tiratsuyan International Conference on Nanotechnologies and Biomedical Engineering . 2020

机译：槲皮素与铜绿假单胞菌Lasr的相互作用：通过法定传感抑制毒力的机械洞察
5. Quorum sensing in Pseudomonas aeruginosa: Design, synthesis and analysis of autoinducer analogs as antagonists for the quorum sensing pathway. [D] . Jog, Geetanjali J. 2005

机译：铜绿假单胞菌的群体感应：设计，合成和分析自动诱导类似物作为群体感应途径的拮抗剂。
6. Effects of Quorum Sensing Systems on Regulatory T Cells in Catheter-Related Pseudomonas aeruginosa Biofilm Infection Rat Models [O] . Lei Feng, Qingqing Xiang, Qing Ai, 2016

机译：群体感应系统对与导管相关的铜绿假单胞菌生物膜感染大鼠模型中调节性T细胞的影响
7. Regulatory Effect of DNA Topoisomerase I on T3SS Activity, Antibiotic Susceptibility and Quorum- Sensing-Independent Pyocyanin Synthesis in Pseudomonas aeruginosa [O] . Rong Yan, Shikun Hu, Ning Ma, 2019

机译：DNA拓扑异构酶I对T3SS活性，抗生素敏感性和Quorum-Custrums-insformsysysysysyssyssysssysments upseconsa铜绿假单胞菌的抗性，抗生素敏感性和批量敏氰酸素合成

Modeling the quorum sensing regulatory network of human-pathogenic Pseudomonas aeruginosa

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