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首页> 外文期刊>Biotechnology Progress >Simulating the embolization of blood vessels using magnetic microparticles and acupuncture needle in a magnetic field
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Simulating the embolization of blood vessels using magnetic microparticles and acupuncture needle in a magnetic field

机译：使用磁性微粒和针灸针在磁场中模拟血管的栓塞

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Computer models were developed to simulate the capture and subsequent deposition of magnetic microparticles (MMPs) in a blood vessel adjacent to a ferromagnetic wire (e.g., acupuncture needle) magnetized by a uniform external magnetic field. Process parameter conditions were obtained to enable optimal capture of MMPs into the deposit. It was found that the maximum capture distance of the MMPs was within 0.5-2.0 mm when the particles were superparamagnetic and had large size (>1.0 mum) and relative large flow rates (2.5-5.0 cm/s) as in a healthy artery. It was also found that the deposits were asymmetrical and that their size was between 1.0 and 2.0 mm. For the case of lower flow rates as can be found in a tumor (< 1.0 mm/s) and using small magnetite particles (0.25-2.0 mum) the maximum capture distance was larger, ranging between approximately 0.5 and 6.4 mm, depending on the blood flow rate, the radius of wire, and particle clustering. The range of embolization (deposition) in this later case was between 0.5 and 5.9 mm. The potential of this technique to generate MMPs deposits to embolize blood vessels inhibiting the blood supply and thus facilitating necrosis of tumors located deep within the patient (3-7 cm) is discussed.
机译：开发了计算机模型以模拟在由均匀外部磁场磁化的铁磁线（例如针灸针）附近的血管中捕获和沉积磁性微粒（MMP）。获得了工艺参数条件，以便能够将MMP最佳捕获到矿床中。发现当颗粒是超顺磁性的并且如健康动脉中那样具有大尺寸（>1.0μm）和相对大的流速（2.5-5.0cm / s）时，MMP的最大捕获距离在0.5-2.0mm内。还发现沉积物是不对称的，并且其尺寸在1.0至2.0mm之间。对于低流速的情况（如在肿瘤中发现的（<1.0 mm / s）并且使用小的磁铁矿颗粒（0.25-2.0微米），最大捕获距离较大，大约在0.5到6.4 mm之间，具体取决于血液流速，金属丝的半径和颗粒聚集。在后一种情况下，栓塞（沉积）范围在0.5到5.9 mm之间。讨论了该技术产生MMP沉积物以栓塞血管从而抑制血液供应并因此促进位于患者深处（3-7 cm）的肿瘤坏死的潜力。

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