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首页> 外文期刊>Dermatologic therapy >Clinical efficacy of dialkylcarbamoylchloride‐coated cotton acetate dressing versus combination of normal saline dressing and 2% mupirocin ointment in infected wounds of epidermolysis bullosa
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Clinical efficacy of dialkylcarbamoylchloride‐coated cotton acetate dressing versus combination of normal saline dressing and 2% mupirocin ointment in infected wounds of epidermolysis bullosa

机译：二烷基氨基甲酰氯化物涂层棉醋酸乙酸醋酸纤维糖浆敷料的临床疗效与红外盐水敷料和2％Mupirocin软膏的表皮分解Bullosa

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Abstract Dialkylcarbamoylchloride (DACC)‐coated cotton acetate dressing works directly through hydrophobic interaction to reduce the number of bacteria without the risk of resistance. It is easy to use and therefore expected to improve patient's compliance. This study aimed to assess the clinical efficacy of DACC‐coated cotton acetate dressing compared to a combination of normal saline dressing and 2% mupirocin ointment. A single‐blind controlled trial was conducted and included 14 infected epidermolysis bullosa (EB) wounds which were divided into two groups. Group I received DACC‐coated cotton acetate dressing, and Group II received the combination of normal saline dressing and 2% mupirocin ointment. Study results showed that the average time required for complete wound closure was 8.6 and 11.1?days in Groups I and II, respectively ( p =?.014), which was statistically significant. Both groups showed complete bacterial elimination on Day 3 based on negative Gram stain results and on Day 6 based on clearance of clinical manifestations ( p =?1.000). This is a novel study in EB‐infected wounds, which shows that DACC‐coated cotton acetate dressing promotes faster wound closure and is as effective as the combination of normal saline dressing and 2% mupirocin ointment in eliminating bacterial infection.
机译：摘要二烷基氨基甲酰氯化物（DACC） - 涂棉醋酸甜酱直接通过疏水性互动，减少细菌的数量，没有抵抗风险。它易于使用，因此预计会改善患者的合规性。本研究旨在评估DACC涂层棉醋酸乙酯敷料的临床疗效与正常盐水敷料和2％Mupirocin软膏的组合相比。进行单盲对照试验并包括14个受感染的表皮溶解Bullosa（EB）伤口，分为两组。群体我收到DACC涂层棉醋酸甜酱，第II组接受了正常盐水敷料和2％Mupirocin软膏的组合。研究结果表明，完全伤口闭合所需的平均时间分别为8.6和11.1℃，分别为统计学意义。两组基于负革克污染结果和第6天，两组在第3天显示完全的细菌消除，并根据临床表现的间隙（P =？1.000）。这是EB感染伤口的一种新型研究，表明DACC涂层棉醋酸甜型敷料促进更快的伤口闭合，并与生理盐水敷料和2％Mupirocin软膏的组合有效，以消除细菌感染。

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