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首页> 外文期刊>Alcohol >Opioid antagonists block the acquisition of ethanol-mediated conditioned tactile preference in infant rats.
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Opioid antagonists block the acquisition of ethanol-mediated conditioned tactile preference in infant rats.

机译：阿片类药物拮抗剂可阻止婴儿介导的乙醇介导的条件触觉偏好的获得。

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摘要

It has been difficult to find conditioned preference for tactile cues paired with ethanol intoxication in rats. Toward understanding the ontogeny of ethanol reinforcement, we aimed at establishing a simple and reliable procedure for (1) assessing primary appetitive conditioning to ethanol in infant rats and (2) discerning the role the opioid system plays in ethanol-mediated conditioning at this age. Experiment 1 determined the parameters (i.e., dose, interval of conditioning) for assessing ethanol-mediated conditioning. Pups were then trained with differential Pavlovian conditioning (Experiments 2 and 3) in which ethanol intoxication (1.0-2.0 g/kg, intragastrically or intraperitoneally delivered) was paired with a tactile stimulus (sandpaper) while an alternative texture signaled the absence of ethanol's effects. Unpaired control conditions were also used. Tactile preferences were assessed after two conditioning sessions. Paired rats spent significantly more time on sandpaper than unpaired controls, an effect that was greater after intragastric administration of 1.0 than 2.0 g/kg ethanol. This effect was replicated in Experiments 4a and 4c and found to be inhibited by pretreatment with general (naloxone [NAL]) or specific (d-Pen-Cys-Tyr-d-Trp-Orn-Thr-Pen-Thr-NH2 [CTOP] and naltrindole) opioid antagonists. Blood ethanol levels at conditioning were not altered by NAL (Experiment 4b). The study outlines a procedure that reveals appetitive conditioning to ethanol by infant rats. The results are discussed in terms of a potential ethanol-induced activation of the endogenous opioid system during the onset of the intoxication process.
机译：在大鼠中很难找到对触觉提示与乙醇中毒配对的条件偏好。为了了解乙醇强化的本体论，我们旨在建立一种简单可靠的程序，用于（1）评估婴儿大鼠对乙醇的主要食欲条件，以及（2）识别阿片样物质系统在该年龄段在乙醇介导的条件中所起的作用。实验1确定了用于评估乙醇介导的调节的参数（即剂量，调节间隔）。然后用差异性巴甫洛夫式调理（实验2和3）训练幼崽，其中乙醇中毒（1.0-2.0 g / kg，通过胃内或腹膜内递送）与触觉刺激（沙纸）配对，而另一种质地则表明没有乙醇的作用。还使用未配对的对照条件。在两次条件训练后评估触觉偏好。配对的大鼠比未配对的对照组在砂纸上花费的时间明显更多，这种效果在胃内给药1.0后比2.0 g / kg乙醇更大。在实验4a和4c中复制了这种效果，并发现通过用一般（纳洛酮[NAL]）或特异性（d-Pen-Cys-Tyr-d-Trp-Orn-Thr-Pen-Thr-NH2 [CTOP ]和naltrindole）阿片类拮抗剂。调节条件下的血液乙醇水平没有被NAL改变（实验4b）。这项研究概述了揭示婴儿大鼠对乙醇的食性调理的程序。根据中毒过程开始期间潜在的乙醇诱导的内源性阿片样物质系统的激活来讨论结果。

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