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首页> 外文期刊>Alcohol >Maternal smoking, alcohol, and coffee use during pregnancy and son's risk of testicular cancer.
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Maternal smoking, alcohol, and coffee use during pregnancy and son's risk of testicular cancer.

机译：孕期孕妇吸烟，饮酒和喝咖啡以及儿子患睾丸癌的风险。

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It has been suggested that increased risk for testicular cancer occurring worldwide may be due to exposures during fetal development. Lifestyle or environmental exposures may be the most important predictors of risk. However, few studies have directly examined these exposures prospectively. The Child Health and Development Studies is a 40-year follow-up of 20,530 pregnancies occurring between 1959 and 1967. There were 20 cases of testicular cancer diagnosed through 2003 among sons with a maternal interview in early pregnancy. Cases were matched to three controls on birth year and race. Odds ratios and 95% confidence intervals were calculated with exact conditional logistic regression. Compared to controls, mothers of testicular cancer cases were more likely to drink alcohol (unadjusted odds ratio, 3.2; 95% confidence interval, 0.83-15.48 for above vs. below the median for controls) and less likely to drink coffee (unadjusted odds ratio, 0.19; 95% confidence interval, 0.02-1.02 for above vs. below the median). Case mothers were neither more nor less likely to smoke. Although low power may limit interpretation of negative results, the prospective design minimizes bias. In this cohort, maternal serum testosterone in pregnancy was previously reported to be lower in women who drank alcohol. Because populations with high testicular cancer risk also have lower maternal testosterone, we suggest that testosterone could play a role in explaining the higher risk of son's testicular cancer among mothers who drank alcohol during pregnancy.
机译：已经提出，全世界范围内发生睾丸癌的风险增加可能是由于胎儿发育期间的暴露。生活方式或环境暴露可能是最重要的风险预测指标。但是，很少有研究直接对这些暴露进行前瞻性检查。儿童健康与发展研究是对1959年至1967年间发生的20,530例妊娠的40年随访。截至2003年，在接受孕早期母体访谈的儿子中，有20例被诊断为睾丸癌。将病例与出生年份和种族的三个对照相匹配。通过精确的条件逻辑回归计算出赔率和95％置信区间。与对照组相比，睾丸癌病例的母亲饮酒的可能性更高（未调整的优势比，3.2; 95％置信区间，相对于中位数，低于对照的中位数为0.83-15.48），而喝咖啡的可能性更低（未调整的优势比） ，0.19; 95％置信区间，中位数之上与之下的0.02-1.02）。案例中的母亲吸烟的可能性既不高也不低。尽管低功率可能会限制对负面结果的解释，但前瞻性设计可最大程度地减少偏差。在这个队列中，以前有报告说喝酒的女性孕妇的血清睾丸激素水平较低。由于具有较高睾丸癌风险的人群的孕产妇睾丸激素水平也较低，因此我们建议，睾丸激素可能在解释怀孕期间饮酒的母亲中儿子患睾丸癌的风险较高方面起作用。

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