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Stress-related neuropeptides and alcoholism: CRH, NPY, and beyond.

机译：与压力有关的神经肽和酒精中毒：CRH，NPY等。

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This article summarizes the proceedings of a symposium held at the conference on Alcoholism and Stress: A Framework for Future Treatment Strategies Italy, May 6-9, 2008. Chaired by Markus Heilig and Roberto Ciccocioppo, this symposium offered a forum for the presentation of recent data linking neuropetidergic neurotransmission to the regulation of different alcohol-related behaviors in animals and in humans. Dr. Donald Gehlert described the development of a new corticotrophin-releasing factor receptor 1 antagonist and showed its efficacy in reducing alcohol consumption and stress-induced relapse in different animal models of alcohol abuse. Dr. Andrey Ryabinin reviewed recent findings in his laboratory, indicating a role of the urocortin 1 receptor system in the regulation of alcohol intake. Dr. Annika Thorsell showed data supporting the significance of the neuropeptide Y receptor system in the modulation of behaviors associated with a history of ethanol intoxication. Dr. Roberto Ciccocioppo focused his presentation on the nociceptin/orphanin FQ (N/OFQ) receptors as treatment targets for alcoholism. Finally, Dr. Markus Heilig showed recent preclinical and clinical evidence suggesting that neurokinin 1 antagonism may represent a promising new treatment for alcoholism. Collectively, these investigators highlighted the significance of neuropeptidergic neurotransmission in the regulation of neurobiological mechanisms of alcohol addiction. Data also revealed the importance of these systems as treatment targets for the development of new medication for alcoholism.
机译：本文总结了在“酒精中毒和压力：未来治疗策略的框架”会议上于2008年5月6日至9日在意大利举行的研讨会的议事情况。该研讨会由Markus Heilig和Roberto Ciccocioppo主持，为最近的演讲提供了一个论坛数据将神经上皮能神经传递与动物和人类不同酒精相关行为的调节联系起来。 Donald Gehlert博士描述了一种新的促肾上腺皮质激素释放因子受体1拮抗剂的开发，并显示了其在不同酒精滥用动物模型中减少酒精消耗和应激诱导的复发的功效。 Andrey Ryabinin博士回顾了他实验室中的最新发现，表明urocortin 1受体系统在酒精摄入调节中的作用。 Annika Thorsell博士展示了支持神经肽Y受体系统在调节与酒精中毒史相关的行为中的重要性的数据。 Roberto Ciccocioppo博士的演讲重点是作为酒精中毒治疗靶点的伤害感受素/孤儿啡FQ（N / OFQ）受体。最后，马库斯·海里格（Markus Heilig）博士展示了最近的临床前和临床证据，表明神经激肽1拮抗作用可能代表着一种有前途的酒精中毒新疗法。这些研究者共同强调了神经肽能神经传递在酒精成瘾的神经生物学机制调控中的重要性。数据还揭示了这些系统作为开发用于酒精中毒的新药物的治疗目标的重要性。

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